Pena-Verdeal Hugo, Garcia-Queiruga Jacobo, Sabucedo-Villamarin Belen, Garcia-Resua Carlos, Giraldez Maria J, Yebra-Pimentel Eva
GI-2092-Optometría, Departamento de Física Aplicada (Área de Optometría), Facultade de Óptica e Optometría, Universidade de Santiago de Compostela, Campus Vida S/N, 15705 Santiago de Compostela, Spain.
Instituto de Investigación Sanitaria (IDIS), Travesía da Choupana S/N, 15706 Santiago de Compostela, Spain.
J Clin Med. 2024 Jan 23;13(3):659. doi: 10.3390/jcm13030659.
(1) Background: Dry eye disease (DED) is a chronic ocular surface condition that requires precise diagnostic tools. The present study aimed to investigate the diagnostic potential of the absolute inter-eye difference (|OD-OS|) in tear meniscus height (TMH) for the detection of the presence of aqueous deficient dry eye (ADDE). (2) Methods: A sample of 260 participants with dry eye complaints underwent ocular surface examinations thorough diagnostic assessments based on the Tear Film and Ocular Surface Society guidelines (TFOS DEWS II). Participants were subsequently categorized as No ADDE and ADDE based on TMH. Statistical analyses to determine the optimal TMH|OD-OS| cut-off value in a randomly selected study group (200 participants) were performed, while a separate validation analysis of the cut-off value obtained in a random cross-validation group (60 participants) was also performed. (3) Results: The significant diagnostic capability of TMH|OD-OS| (area under the curve = 0.719 ± 0.036, < 0.001) was found. The identified cut-off value of 0.033 mm demonstrated reliable specificity (77.6%) and moderate sensitivity (59.1%). Cross-validation confirmed the cut-off value's association with the TFOS DEWS II diagnostic criterion (Cramer's V = 0.354, = 0.006). (4) Conclusions: The present study provides evidence for the diagnostic potential of TMH|OD-OS| in identifying ADDE. The identified cut-off value enhances the specificity and offers moderate sensitivity, providing an objective tool for clinical decision making.
（1）背景：干眼疾病（DED）是一种慢性眼表疾病，需要精确的诊断工具。本研究旨在探讨泪河高度（TMH）的双眼绝对差值（|OD - OS|）对检测水液缺乏型干眼（ADDE）的诊断潜力。（2）方法：对260名有干眼症状的参与者进行眼表检查，根据泪膜与眼表协会指南（TFOS DEWS II）进行全面诊断评估。随后根据TMH将参与者分为非ADDE组和ADDE组。在一个随机选择的研究组（200名参与者）中进行统计分析，以确定最佳的TMH|OD - OS|截断值，同时在一个随机交叉验证组（60名参与者）中对获得的截断值进行单独的验证分析。（3）结果：发现TMH|OD - OS|具有显著的诊断能力（曲线下面积 = 0.719 ± 0.036，P < 0.001）。确定的截断值为0.033 mm，显示出可靠的特异性（77.6%）和中等敏感性（59.1%）。交叉验证证实了截断值与TFOS DEWS II诊断标准的相关性（克莱默V系数 = 0.354，P = 0.006）。（4）结论：本研究为TMH|OD - OS|在识别ADDE方面的诊断潜力提供了证据。确定的截断值提高了特异性并提供了中等敏感性，为临床决策提供了一个客观工具。
