果蝇翅膀试验：不同品系敏感性的比较

The Drosophila wing test: a comparison of the sensitivity of different strains.

作者信息

Clements J, Howe D, Phillips M, Todd N K

机构信息

Department of Biology, University of York, Heslington, Great Britain.

出版信息

Mutat Res. 1988 Apr;203(2):117-23. doi: 10.1016/0165-1161(88)90026-x.

DOI:10.1016/0165-1161(88)90026-x

PMID:3127702

Abstract

A range of 5 chemical mutagens were tested in the Drosophila wing test using 2 different strains and carrying out the experiments in parallel under standardised conditions. The mutagens chosen for the study were the 2 alkylating agents MMS and ENU and the anti-cancer drugs methotrexate, cytosine-arabinoside and adriamycin. As a result of the different genetic backgrounds there was a marked variation in the response of the 2 strains to the mutagens.

摘要

在果蝇翅测试中，使用2种不同品系，并在标准化条件下并行开展实验，对5种化学诱变剂进行了测试。本研究选用的诱变剂为2种烷化剂甲磺酸甲酯（MMS）和N-乙基-N-亚硝基脲（ENU），以及抗癌药物甲氨蝶呤、阿糖胞苷和阿霉素。由于遗传背景不同，这2种品系对诱变剂的反应存在显著差异。