口服免疫球蛋白Y治疗婴幼儿轮状病毒肠炎的临床疗效：系统评价与Meta分析
Clinical efficacy of oral immunoglobulin Y in infant rotavirus enteritis: Systematic review and meta-analysis.
作者信息
Wang Xiaotong, Song Lijun, Tan Wenpan, Zhao Wenchang
机构信息
School of Pharmacy, Guangdong Medical University, Dongguan.
Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical University, Zhanjiang, Guangdong, China.
出版信息
Medicine (Baltimore). 2019 Jul;98(27):e16100. doi: 10.1097/MD.0000000000016100.
BACKGROUND
Rotavirus (RV) can cause vomiting and diarrhea in infants and children, and could be treated clinically with immunoglobulin Y (IgY), which is an immunoglobulin extracted from chicken yolk. There is no systematic evaluation of immunoglobulin in the treatment of rotavirus enteritis. Therefore, we systematically evaluated rotavirus enteritis with oral immunoglobulin Y therapy using meta-analysis.
METHODS
We conducted a systematic search in CNKI, WANFANG DATA, VIP, PubMed, and the Cochrane Library databases (up to April 30, 2018). Using Revman 5.3 software for meta-analysis.
RESULTS
A total of 2626 subjects with rotavirus diarrhea from 17 randomized clinical trials were included in the meta-analysis. Of these, 1347 subjects received oral immunoglobulin Y and 1279 subjects received conventional treatment. The results of the meta-analysis indicated that the total number of effective cases and effective rates of immunoglobulin Y in treatment of rotavirus enteritis in infants and children was statistically different from that in the control group (odds ratio [OR] = 3.87, 95% confidence interval [CI] (3.17, 4.74), P < .00001) and (OR = 3.63, 95% CI [2.75, 4.80], P < .00001).
CONCLUSIONS
Immunoglobulin Y is effective in the treatment of infantile rotavirus enteritis. Oral immunoglobulin Y can be widely used in the treatment of rotavirus enteritis in clinic.
背景
轮状病毒（RV）可引起婴幼儿呕吐和腹泻，临床上可用从鸡卵黄中提取的免疫球蛋白Y（IgY）进行治疗。目前尚无关于免疫球蛋白治疗轮状病毒肠炎的系统评价。因此，我们采用Meta分析系统评价口服免疫球蛋白Y治疗轮状病毒肠炎的疗效。
方法
我们在CNKI、万方数据、维普、PubMed和Cochrane图书馆数据库中进行了系统检索（截至2018年4月30日）。使用Revman 5.3软件进行Meta分析。
结果
共有来自17项随机临床试验的2626例轮状病毒腹泻患者纳入Meta分析。其中，1347例患者接受口服免疫球蛋白Y治疗，1279例患者接受常规治疗。Meta分析结果显示，免疫球蛋白Y治疗婴幼儿轮状病毒肠炎的有效病例总数和有效率与对照组相比有统计学差异（优势比[OR]=3.87，95%置信区间[CI]（3.17，4.74），P<0.00001）和（OR=3.63，95%CI[2.75，4.80]，P<0.00001）。
结论
免疫球蛋白Y治疗婴幼儿轮状病毒肠炎有效。口服免疫球蛋白Y可在临床上广泛用于治疗轮状病毒肠炎。
Zotero 插件