Adhvaryu S G, Rawal U M, Patel J V
Cell Biology Division, Gujarat Cancer and Research Institute, Ahmedabad, India.
Neoplasma. 1988;35(1):103-8.
Sister chromatid exchange (SCE) frequencies were studied in normal and mutagen-treated lymphocyte cultures from patients with ovarian carcinoma and controls. The mean SCE value per cell in normal cultures from the patients was 7.84 which was significantly higher than 6.41 SCEs per cell observed in the controls (p less than 0.01). Similar SCE values obtained for mutagen (mitomycin C, MMC) treated cultures were somewhat lower for patients as compared to the controls, however, the difference was not significant. Cellular kinetics, expressed as average generation time (AGT), was suppressed in lymphocyte cultures from ovarian carcinoma patients as compared to the controls (p much less than 0.05). It was concluded that although baseline SCE rates in lymphocytes of patients with ovarian carcinoma were higher as compared to the controls, they have very limited application as a marker malignancy.
研究了卵巢癌患者和对照组正常及经诱变剂处理的淋巴细胞培养物中的姐妹染色单体交换（SCE）频率。患者正常培养物中每个细胞的平均SCE值为7.84，显著高于对照组中观察到的每个细胞6.41个SCE（p小于0.01）。与对照组相比，经诱变剂（丝裂霉素C，MMC）处理的培养物中患者获得的类似SCE值略低，然而，差异不显著。与对照组相比，卵巢癌患者淋巴细胞培养物中的细胞动力学，以平均世代时间（AGT）表示，受到抑制（p远小于0.05）。得出的结论是，尽管卵巢癌患者淋巴细胞中的基线SCE率高于对照组，但它们作为恶性肿瘤标志物的应用非常有限。
