Department of Obstetrics & Gynecology, Tufts University School of Medicine, Boston, MA 02111, USA.
Mother Infant Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
Int J Mol Sci. 2019 Jul 4;20(13):3283. doi: 10.3390/ijms20133283.
Iron is an essential element for the survival of most organisms, including humans. Demand for iron increases significantly during pregnancy to support growth and development of the fetus. Paradoxically, epidemiologic studies have shown that excessive iron intake and/or high iron status can be detrimental to pregnancy and is associated with reproductive disorders ranging from endometriosis to preeclampsia. Reproductive complications resulting from iron deficiency have been reviewed elsewhere. Here, we focus on reproductive disorders associated with iron overload and the contribution of ferroptosis-programmed cell death mediated by iron-dependent lipid peroxidation within cell membranes-using preeclampsia as a model system. We propose that the clinical expressions of many reproductive disorders and pregnancy complications may be due to an underlying ferroptopathy (elemental iron-associated disease), characterized by a dysregulation in iron homeostasis leading to excessive ferroptosis.
铁是大多数生物体（包括人类）生存所必需的元素。怀孕期间对铁的需求显著增加，以支持胎儿的生长和发育。矛盾的是，流行病学研究表明，过量的铁摄入和/或高铁状态可能对怀孕有害，并与从子宫内膜异位症到子痫前期等生殖障碍有关。铁缺乏引起的生殖并发症已在其他地方进行了综述。在这里，我们专注于与铁过载相关的生殖障碍，以及铁依赖性脂质过氧化介导的铁死亡程序细胞死亡（使用子痫前期作为模型系统）的贡献。我们提出，许多生殖障碍和妊娠并发症的临床表现可能是由于潜在的铁病变（与元素铁相关的疾病）引起的，其特征是铁稳态失调导致铁死亡过度。
