Nucleus of Research in Biological Sciences (NUPEB), Federal University of Ouro Preto, Ouro Preto, MG, Brasil.
School of Nutrition, Federal University of Ouro Preto, Ouro Preto, MG, Brasil.
Eur J Nutr. 2020 Aug;59(5):1895-1908. doi: 10.1007/s00394-019-02040-2. Epub 2019 Jul 5.
Maternal high-fat diet affects offspring and can induce metabolic disorders such as non-alcoholic fatty liver disease (NAFLD). New therapeutic strategies are being investigated as way to prevent or attenuate this condition. The objective of this study was to evaluate the effect of açaí supplementation in the maternal high-fat diet on dams and offspring lipid metabolism.
Female Fisher rats were divided in four groups and fed a control diet (C), a high-fat diet (HF), an açaí supplemented diet (CA) and a high-fat diet supplemented with açaí (HFA) 2 weeks before mating, during gestation and lactation. The effects of açaí were evaluated in the male offspring after birth (P1) and weaning (P21).
HFA reduced relative liver weight, fat and cholesterol liver content in dams and improved liver steatosis as confirmed by histological analyses. HFA increased serum cholesterol and expression of Srebpf1 and Fasn genes. In offspring, HFA decreased relative liver weight, and serum cholesterol only in P21. An increase in the Sirt1, Srebpf1 and Fasn genes expression was observed in P21.
These results suggest that açaí supplementation may attenuate NAFLD in dams and protect offspring from the detrimental effects of lipid excess from a maternal high-fat diet.
母体高脂肪饮食会影响后代，并可诱发非酒精性脂肪肝疾病（NAFLD）等代谢紊乱。目前正在研究新的治疗策略，以预防或减轻这种情况。本研究的目的是评估在母体高脂肪饮食中添加巴西莓对母鼠及其后代脂质代谢的影响。
雌性 Fisher 大鼠分为四组，在交配前 2 周、妊娠期和哺乳期分别喂食对照饮食（C）、高脂肪饮食（HF）、巴西莓补充饮食（CA）和高脂肪饮食补充巴西莓（HFA）。在出生后（P1）和断奶后（P21）评估巴西莓对雄性后代的影响。
HFA 降低了母体的肝重、肝脂肪和胆固醇含量，并通过组织学分析改善了肝脂肪变性。HFA 增加了血清胆固醇和 Srebpf1 和 Fasn 基因的表达。在后代中，HFA 仅在 P21 时降低了相对肝重和血清胆固醇。在 P21 时观察到 Sirt1、Srebpf1 和 Fasn 基因表达增加。
这些结果表明，巴西莓补充剂可能减轻母体高脂肪饮食引起的母鼠的 NAFLD，并保护后代免受脂质过量的不利影响。
