University of Richmond, USA.
University of Richmond, USA.
Neurosci Biobehav Rev. 2019 Sep;104:191-196. doi: 10.1016/j.neubiorev.2019.06.034. Epub 2019 Jul 3.
Pioneering comparative neuroendocrinologist Frank Beach cautioned researchers of the dangers of investing too much research energy in a single species (i.e., the laboratory rat) in the pursuit of limited behavioral investigations (e.g., learning) in his 1950 article entitled The snark was a boojum. Over a half-century later, behavioral neuroscientists continue to focus disproportionately on rodent models and, although exciting cutting-edge neuroscience techniques are currently utilized, the sophistication of behavioral approaches often lag behind these neurobiological methodological tools. The predictable, sterile laboratory environments, referred to as niceties by Beach, also present challenges to the investigation of relevant, species-specific responses to unpredictable natural environments. As more attention is directed to these methodological issues, fundamental information about nervous systems, as well as the translational value of studies utilizing various animal models, will be enhanced.
开创性的比较神经内分泌学家弗兰克·比奇(Frank Beach)在他 1950 年题为《斯纳克是布约姆》的文章中警告研究人员,在追求有限的行为研究(例如学习)时,不要将过多的研究精力投入到单一物种(即实验室大鼠)中。半个多世纪后,行为神经科学家继续不成比例地关注啮齿动物模型,尽管目前正在使用令人兴奋的前沿神经科学技术,但行为方法的复杂性往往落后于这些神经生物学方法工具。比奇(Beach)称之为“niceties”的可预测、无菌的实验室环境也给研究与不可预测的自然环境相关的特定物种反应带来了挑战。随着更多的注意力转向这些方法问题,有关神经系统的基本信息以及利用各种动物模型进行研究的转化价值将得到提高。