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野生大脑:神经行为学方法在临床前行为神经科学动物模型中的价值

Wild brains: The value of neuroethological approaches in preclinical behavioral neuroscience animal models.

作者信息

Lambert Kelly

机构信息

Behavioral Neuroscience, University of Richmond, USA.

出版信息

Neurosci Biobehav Rev. 2023 Mar;146:105044. doi: 10.1016/j.neubiorev.2023.105044. Epub 2023 Jan 11.

Abstract

For three decades, IBNS has provided a forum for the dissemination of behavioral neuroscience research, broadly defined. Throughout this time, research presented at the annual meetings has reflected representative trends in the field with an emphasis on relevant preclinical animal models. From its inception, IBNS has contributed to my professional development and evolving research interests. Unsurprisingly, throughout the three decades of its existence, IBNS annual programs have reflected research trends that have been thoughtfully evaluated, challenged, and, in some cases, recalibrated. An emphasis in my lab, for example, has slowly navigated toward the inclusion of more diverse species (e.g., nonhuman primate models, wild rats, wild and captive raccoons) assessed in settings that reflect more ethological relevance than typically observed in traditional laboratory settings. Consequently, my research interests are pivoting from laboratory animal model exclusive (L.A.M.E.) endeavors to more natural, diverse, ethoexperimental approaches. As progress toward translational findings for psychiatric and neurological conditions is considered, it is recommended that researchers remain open to nontraditional methodological approaches that incorporate diverse animal models and assessments to inform laboratory-generated findings.

摘要

三十年来,国际行为神经科学学会(IBNS)为广义上的行为神经科学研究成果传播提供了一个平台。在此期间,年会上展示的研究反映了该领域的代表性趋势,重点是相关的临床前动物模型。自成立以来,IBNS对我的职业发展和不断演变的研究兴趣起到了推动作用。不出所料,在其存在的三十年里,IBNS的年度项目反映了经过深思熟虑评估、受到挑战且在某些情况下重新校准的研究趋势。例如,我实验室的重点已逐渐转向纳入更多样化的物种(如非人类灵长类动物模型、野生大鼠、野生和圈养浣熊),这些物种在比传统实验室环境更具行为学相关性的环境中进行评估。因此,我的研究兴趣正从单纯的实验动物模型(L.A.M.E.)研究转向更自然、多样的行为实验方法。在考虑精神和神经疾病转化研究成果的进展时,建议研究人员对非传统方法保持开放态度,这些方法纳入了多样化的动物模型和评估,以指导实验室研究结果。

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