Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, 4710-057 Braga/Guimarães, Portugal; Clinical Academic Center - Braga, 4710-057 Braga, Portugal.
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, 4710-057 Braga, Portugal; ICVS/3B's, PT Government Associate Laboratory, 4710-057 Braga/Guimarães, Portugal; Clinical Academic Center - Braga, 4710-057 Braga, Portugal.
Psychiatry Res Neuroimaging. 2019 Aug 30;290:38-41. doi: 10.1016/j.pscychresns.2019.06.008. Epub 2019 Jul 2.
Obsessive-compulsive disorder (OCD) is one of the most debilitating psychiatric conditions, having a dramatic impact on patients' daily living. In this work, we aimed to explore resting-state functional connectivity in OCD patients, using an independent component analysis. Eighty individuals (40 patients and 40 healthy controls) performed a resting state fMRI protocol. OCD patients displayed reduced functional connectivity (FC) in visual and sensorimotor networks. In addition, patients displayed decreased FC between sensory networks and increased FC between default-mode and cerebellar networks.
强迫症（OCD）是一种最具致残性的精神疾病之一，对患者的日常生活有重大影响。在这项工作中，我们使用独立成分分析来探索强迫症患者的静息态功能连接。80 名个体（40 名患者和 40 名健康对照）完成了静息态 fMRI 方案。强迫症患者的视觉和感觉运动网络的功能连接（FC）减少。此外，患者表现出感觉网络之间的 FC 减少，默认模式和小脑网络之间的 FC 增加。
