Department of Neurosurgery, The Hangzhou Hospital of Traditional Chinese Medicine, The Guangxing Hospital Affiliated to Zhejiang Chinese Medical University, 453 Tiyuchang Road, Hangzhou 310007, China.
Department of Neurosurgery, The Hangzhou Hospital of Traditional Chinese Medicine, The Guangxing Hospital Affiliated to Zhejiang Chinese Medical University, 453 Tiyuchang Road, Hangzhou 310007, China.
Clin Chim Acta. 2019 Oct;497:6-12. doi: 10.1016/j.cca.2019.07.008. Epub 2019 Jul 4.
Interleukin-33 is recently identified as a brain injury biomarker. We determined whether serum interlerukin-33 concentrations are associated with inflammation, severity and prognosis after traumatic brain injury (TBI).
We detected serum interlerukin-33 concentrations of 102 healthy controls and 102 severe TBI patients, as well as serum concentrations of 3 inflammatory biomarkers (interleukin-6, tumor necrosis factor-alpha and C-reactive protein) and 7 cell-specific proteins (myelin basic protein, glial fibrillary astrocyte protein, S100B, neuron-specific enolase, phosphorylated axonal neurofilament subunit H, Tau and ubiquitin carboxyl-terminal hydrolase L1) in 102 severe TBI patients. The recorded poor prognosis variables included acute lung injury, acute traumatic coagulopathy, progressive hemorrhagic injury, posttraumatic cerebral infarction and six-month mortality and poor outcome (Glasgow score of 1-3).
Median interlerukin-33 concentration of patients (692 pg/mL) was substantially raised, as compared to controls. Interlerukin-33 concentrations were significantly correlated with Glasgow coma scale (GCS) score and the preceding biomarkers concentrations. Interlerukin-33 concentration > 692 pg/mL emerged as an independent prognostic predictor and its discriminatory capability exceeded those of the above-mentioned inflammatory biomarkers concentrations and was in the range of GCS scores and the aforementioned cell-specific proteins concentrations.
Ascending serum interlerukin-33 concentrations could reflect inflammation, severity and worse prognosis following TBI.
白细胞介素-33 最近被确定为脑损伤的生物标志物。我们确定了血清白细胞介素-33 浓度是否与创伤性脑损伤（TBI）后的炎症、严重程度和预后相关。
我们检测了 102 名健康对照者和 102 名严重 TBI 患者的血清白细胞介素-33 浓度，以及 102 名严重 TBI 患者的 3 种炎症生物标志物（白细胞介素-6、肿瘤坏死因子-α和 C 反应蛋白）和 7 种细胞特异性蛋白（髓鞘碱性蛋白、胶质纤维酸性蛋白、S100B、神经元特异性烯醇化酶、磷酸化轴突神经丝重链 H、Tau 和泛素羧基末端水解酶 L1）的血清浓度。记录的预后不良变量包括急性肺损伤、急性创伤性凝血病、进行性出血性损伤、创伤后脑梗死和 6 个月死亡率和不良预后（格拉斯哥评分 1-3）。
与对照组相比，患者的中位白细胞介素-33 浓度（692pg/ml）明显升高。白细胞介素-33 浓度与格拉斯哥昏迷评分（GCS）评分和先前的生物标志物浓度显著相关。白细胞介素-33 浓度>692pg/ml 是一个独立的预后预测因子，其判别能力超过了上述炎症生物标志物浓度，与 GCS 评分和上述细胞特异性蛋白浓度相当。
血清白细胞介素-33 浓度的升高可能反映了 TBI 后的炎症、严重程度和不良预后。
