Martin M E, Dewar J B, Newman J F
Department of Microbiology, Rhodes University, Grahamstown, South Africa.
Vaccine. 1988 Feb;6(1):33-8. doi: 10.1016/0264-410x(88)90011-4.
Experimental vaccines have been made by co-polymerizing virus particles and virus subunits into rabbit serum albumin beads. When injected into rabbits these model vaccines induced specific humoral antibody production and mimicked vaccines prepared using Freund's incomplete adjuvant. No adverse reactions occurred in experimental rabbits and no antibodies reacting with polymerized rabbit serum albumin beads were found. Immunostimulation is attributed to a slow release of antigen coinciding with the gradual breakdown of bead structure.
实验性疫苗是通过将病毒颗粒和病毒亚基与兔血清白蛋白珠共聚合制成的。将这些模型疫苗注射到兔子体内后，可诱导产生特异性体液抗体，并模拟使用弗氏不完全佐剂制备的疫苗。实验兔子未出现不良反应，也未发现与聚合兔血清白蛋白珠发生反应的抗体。免疫刺激归因于抗原的缓慢释放，这与珠子结构的逐渐分解相吻合。
