Langhein C, Newman J F
Department of Microbiology, Rhodes University, Grahamstown, South Africa.
J Appl Bacteriol. 1987 Nov;63(5):443-8. doi: 10.1111/j.1365-2672.1987.tb04866.x.
Model vaccines have been made by covalently linking Clostridium botulinum type D toxin and Klebsiella pneumoniae capsular polysaccharide antigen to polymerized rabbit serum albumin beads. When injected into rabbits these bead vaccines induced an enhanced production of specific humoral antibody without causing adverse reactions. The adjuvant effect is due to a slow release from the bead structure and offers an alternative to oil emulsions and mineral salt adsorbents.
已通过将D型肉毒梭菌毒素和肺炎克雷伯菌荚膜多糖抗原共价连接到聚合兔血清白蛋白珠上制备了模型疫苗。将这些珠疫苗注射到兔子体内时，可诱导特异性体液抗体产生增加，且不会引起不良反应。佐剂效应归因于从珠结构的缓慢释放，为油乳剂和矿物盐吸附剂提供了一种替代选择。
