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远红外线对替莫唑胺治疗大鼠胶质瘤的影响。

Effects of Far-infrared Ray on Temozolomide-treated Glioma in Rats.

机构信息

Department of Neurosurgery, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan, R.O.C.

School of Medicine, Tzu Chi University, Hualien, Taiwan, R.O.C.

出版信息

In Vivo. 2019 Jul-Aug;33(4):1203-1208. doi: 10.21873/invivo.11591.

DOI:10.21873/invivo.11591
PMID:31280210
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6689335/
Abstract

BACKGROUND/AIM: Malignant glioma is a rapidly progressive primary brain cancer. The aim of the study was to investigate the effect of far-infrared ray (FIR) on temozolomide (TMZ)-treated glioma in rats.

MATERIALS AND METHODS

Male, 8-week old, Fischer 344 inbred rats with glioma were randomly divided into three study groups (20 rats in each group). The control group received saline only once daily for 5 days. The TMZ group received TMZ (30 mg/kg) once daily for 5 days. The TMZ plus FIR group received TMZ (30 mg/kg) once daily for 5 days and infrared-c irradiation of 40 min twice daily for 4 weeks. The relative tumor fold and the expression of hypoxia-induced factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) were compared using one-way ANOVA at the end of study.

RESULTS

The relative tumor fold of the TMZ+FIR group was significantly higher compared to the control group, and was borderline higher compared to the TMZ group at Day 7. The relative tumor fold of TMZ+FIR group was significantly higher compared to the control group and the TMZ group at Days 14, 21 and 28. HIF-1α expression of TMZ+FIR group was borderline higher compared to the control group at Day 28. The VEGF expression of TMZ+FIR group was significantly higher compared to the control group and the TMZ group at Day 28.

CONCLUSION

FIR might increase the growth of glioma under TMZ treatment in rats possibly via increasing VEGF expression, but not HIF-1α expression.

摘要

背景/目的：恶性胶质瘤是一种快速进展的原发性脑癌。本研究旨在探讨远红外线（FIR）对替莫唑胺（TMZ）治疗大鼠胶质瘤的影响。

材料和方法

雄性、8 周龄、近交系 Fischer 344 大鼠脑胶质瘤，随机分为三组（每组 20 只）。对照组每天仅接受生理盐水一次，共 5 天。TMZ 组每天接受 TMZ（30mg/kg）一次，共 5 天。TMZ+FIR 组每天接受 TMZ（30mg/kg）一次，共 5 天，并接受为期 4 周、每天两次、每次 40 分钟的红外线照射。在研究结束时，使用单因素方差分析比较各组的相对肿瘤倍数以及缺氧诱导因子-1α（HIF-1α）和血管内皮生长因子（VEGF）的表达。

结果

TMZ+FIR 组的相对肿瘤倍数在第 7 天与对照组相比显著升高，与 TMZ 组相比略高。TMZ+FIR 组的相对肿瘤倍数在第 14、21 和 28 天与对照组和 TMZ 组相比均显著升高。TMZ+FIR 组在第 28 天的 HIF-1α 表达与对照组相比略高。TMZ+FIR 组在第 28 天的 VEGF 表达与对照组和 TMZ 组相比均显著升高。

结论

FIR 可能通过增加 VEGF 表达而不是 HIF-1α 表达，增加 TMZ 治疗大鼠胶质瘤的生长。