Muchmore A V, Decker J M, Blaese R M
J Immunol. 1979 Mar;122(3):1152-5.
In a previous paper we demonstrated that freshly obtained human plasma contain a heat labile nonantibody factor that induced human mononuclear cells to become nonspecifically cytotoxic toward xenogeneic but not allogeneic RBC targets. We now present evidence that this factor has a loose affinity for human monocytes and human T cells and can arm then to kill xenogeneic RBC targets. Furthermore, proteolytic enzymes markedly enhance this arming effect. This ability to be armed by a heat labile component found in fresh human plasma and the fact that proteolytic enzymes markedly enhance cytotoxicity clearly dissociate this model of nonspecific cytotoxicity for previously reported NK models.
在之前的一篇论文中，我们证明了新鲜获取的人血浆中含有一种热不稳定的非抗体因子，该因子可诱导人单核细胞对异种但非同种异体红细胞靶标产生非特异性细胞毒性。我们现在提供证据表明，该因子与人单核细胞和人T细胞具有较弱的亲和力，并且能够武装它们以杀伤异种红细胞靶标。此外，蛋白水解酶可显著增强这种武装效应。这种被新鲜人血浆中发现的热不稳定成分武装的能力，以及蛋白水解酶显著增强细胞毒性这一事实，显然将这种非特异性细胞毒性模型与先前报道的自然杀伤（NK）模型区分开来。
