Department of Dermatology and Allergy Centre, Odense University Hospital, University of Southern Denmark, Odense, Denmark.
Department of Dermatology, Mølholm Private Hospital, Vejle, Denmark.
Contact Dermatitis. 2019 Nov;81(5):374-377. doi: 10.1111/cod.13348. Epub 2019 Jul 31.
Tree moss (Pseudevernia furfuracea [L.] Zopf.), a lichen growing on conifers, is a frequent fragrance sensitizer. Previous studies have shown two subgroups of tree moss-allergic patients: a group sensitized to common allergens of tree and oak moss (Evernia prunastri), and another group sensitized to colophonium-derived allergens, which may contaminate tree moss extract.
To report the results of including tree moss extract in the baseline series and discuss the clinical implications.
Tree moss extract was included in the baseline series and sensitized patients were assessed for concomitant allergy to colophonium and oak moss, and the relevance of these reactions was analyzed.
Altogether, 22 of 632 patients (3.5%) had positive reactions to tree moss. Eight patients were sensitized to tree moss only (among fragrance allergens) and 75% had relevant reactions to colophonium. Fourteen patients were sensitized to other fragrance allergens as well and 28.5% had relevant colophonium reactions.
The prevalence of positive tree moss reactions is high enough to justify its inclusion in the baseline series. If tree moss is not included, patients with positive colophonium reactions should be informed of possible (false) cross-reactivity to tree moss to avoid this labeled fragrance allergen.
树苔（假地鳞衣 Pseudevernia furfuracea [L.] Zopf.）是一种生长在针叶树上的地衣，是一种常见的香料致敏原。先前的研究表明，树苔过敏患者存在两个亚群：一组对树苔和橡苔（Evernia prunastri）的常见过敏原敏感，另一组对可能污染树苔提取物的柯巴脂衍生过敏原敏感。
报告在基线系列中包含树苔提取物的结果，并讨论其临床意义。
将树苔提取物纳入基线系列，评估对树苔过敏的患者是否同时对柯巴脂和橡苔过敏，并分析这些反应的相关性。
共有 632 名患者中的 22 名（3.5%）对树苔呈阳性反应。8 名患者仅对树苔（香料过敏原之一）敏感，其中 75%对柯巴脂有相关反应。14 名患者也对其他香料过敏原敏感，其中 28.5%对柯巴脂有相关反应。
阳性树苔反应的发生率足以证明其纳入基线系列的合理性。如果不包括树苔，对柯巴脂阳性反应的患者应告知其可能存在（假）交叉反应至树苔，以避免这种标记的香料过敏原。
