Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, D-91054 Erlangen, Germany.
Contact Dermatitis. 2012 Jul;67(1):36-41. doi: 10.1111/j.1600-0536.2012.02064.x. Epub 2012 Apr 4.
Evernia prunastri (oak moss) and Evernia furfuracea (tree moss) are lichens from which natural extracts are obtained.
To identify possible subgroups of E. furfuracea-sensitized patients according to whether these are allergic to lichen components or to contaminants.
A retrospective analysis was performed of surveillance data collected by the Information Network of Departments of Dermatology (www.ivkd.org) in 2003-2010 with oak moss absolute (1% pet.), tree moss absolute (1% pet.), and colophonium (colophony, 20% pet.).
In total, 3030 patients had been tested with all three allergens. Positive reactions to E. furfuracea were observed in 6.37%, to E. prunastri in 5.71%, and to colophonium in 4.82%. Concordance between positive reactions to E. prunastri and E. furfuracea was good only in patients not co-sensitized to colophonium (Cohen's κ = 0.681, 95% confidence interval 0.615-0.746). Moreover, E. furfuracea-sensitized patients showed (strong or extreme) concomitant reactions to colophonium significantly more often if not co-sensitized to E. prunastri.
Two subgroups of E. furfuracea-sensitized patients are identifiable: (i) those with sensitization to (oxidized) resin acids, as indicated by positive patch test reactions also to colophonium, and (ii) those non-sensitized to resin acids, but sensitized to common constituents of E. prunastri and E. furfuracea.
扁枝石松（oak moss）和树苔（tree moss）是两种地衣，从中可以提取天然提取物。
根据患者是否对lichen 成分或污染物过敏，确定 E. furfuracea 致敏患者的可能亚组。
对 2003 年至 2010 年通过皮肤病科信息网络（www.ivkd.org）收集的监测数据进行回顾性分析，所用的变应原包括橡苔纯浸膏（1% pet.）、树苔纯浸膏（1% pet.）和松香（colophonium，20% pet.）。
共有 3030 例患者接受了所有三种变应原的检测。对 E. furfuracea 的阳性反应率为 6.37%，对 E. prunastri 的阳性反应率为 5.71%，对 colophonium 的阳性反应率为 4.82%。只有在未同时对 colophonium 致敏的患者中，E. prunastri 和 E. furfuracea 的阳性反应具有良好的一致性（Cohen's κ = 0.681，95%置信区间 0.615-0.746）。此外，如果 E. furfuracea 致敏患者未同时对 E. prunastri 致敏，则对 colophonium 表现出（强或极度）伴随反应的可能性显著更高。
可确定 E. furfuracea 致敏患者存在两种亚组：（i）对（氧化）树脂酸敏感的患者，其斑贴试验对 colophonium 也呈阳性反应；（ii）对树脂酸不敏感但对 E. prunastri 和 E. furfuracea 的常见成分敏感的患者。
