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英国生物样本库开放获取策略对健康研究的优势。

The advantages of UK Biobank's open-access strategy for health research.

机构信息

UK Biobank, Cheadle, Stockport, UK.

Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.

出版信息

J Intern Med. 2019 Oct;286(4):389-397. doi: 10.1111/joim.12955. Epub 2019 Aug 2.

Abstract

Ready access to health research studies is becoming more important as researchers, and their funders, seek to maximize the opportunities for scientific innovation and health improvements. Large-scale population-based prospective studies are particularly useful for multidisciplinary research into the causes, treatment and prevention of many different diseases. UK Biobank has been established as an open-access resource for public health research, with the intention of making the data as widely available as possible in an equitable and transparent manner. Access to UK Biobank's unique breadth of phenotypic and genetic data has attracted researchers worldwide from across academia and industry. As a consequence, it has enabled scientists to perform world-leading collaborative research. Moreover, open access to an already deeply characterized cohort has encouraged both public and private sector investment in further enhancements to make UK Biobank an unparalleled resource for public health research and an exemplar for the development of open-access approaches for other studies.

摘要

随着研究人员及其资助者寻求最大限度地提高科学创新和健康改善的机会,方便获取健康研究成果变得越来越重要。大规模基于人群的前瞻性研究对于多学科研究许多不同疾病的病因、治疗和预防特别有用。英国生物银行已作为公共卫生研究的开放获取资源而建立,旨在以公平和透明的方式尽可能广泛地提供数据。英国生物银行独特的表型和遗传数据广度吸引了来自学术界和工业界的全球研究人员。因此,它使科学家能够开展世界领先的合作研究。此外,对一个已经深入描述的队列进行开放访问,既鼓励了公共和私营部门进一步投资,以增强英国生物银行作为公共卫生研究无与伦比的资源的地位,也为其他研究的开放获取方法的发展树立了典范。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef0a/6790705/52515e39dcc6/JOIM-286-389-g001.jpg

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