英国生物库的前瞻性研究设计和数据分析。
Prospective study design and data analysis in UK Biobank.
机构信息
UK Biobank Ltd, Stockport, UK.
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
出版信息
Sci Transl Med. 2024 Jan 10;16(729):eadf4428. doi: 10.1126/scitranslmed.adf4428.
Abstract
Population-based prospective studies, such as UK Biobank, are valuable for generating and testing hypotheses about the potential causes of human disease. We describe how UK Biobank's study design, data access policies, and approaches to statistical analysis can help to minimize error and improve the interpretability of research findings, with implications for other population-based prospective studies being established worldwide.
摘要
基于人群的前瞻性研究，如英国生物库，对于产生和检验关于人类疾病潜在原因的假设非常有价值。我们描述了英国生物库的研究设计、数据访问政策和统计分析方法如何有助于最小化误差并提高研究结果的可解释性，这对世界范围内正在建立的其他基于人群的前瞻性研究具有启示意义。
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