Hatem M, Anthony F, Hogston P, Rowe D J, Dennis K J
Faculty of Medicine, University of Southampton, Princess Anne Hospital.
Br Med J (Clin Res Ed). 1988 Mar 5;296(6623):676-8. doi: 10.1136/bmj.296.6623.676.
A 75 g oral glucose tolerance test was performed in 212 pregnant women with no predisposing factors suggesting glucose intolerance to establish the normal pattern of glucose metabolism in pregnancy. Reference values for the test were established for the middle of pregnancy (14-20 weeks, n = 43) and late pregnancy (28-37 weeks, n = 168). One woman was excluded because she had diabetes that required treatment with insulin. There were statistically significant differences between the two groups for samples taken both one and two hours after the glucose load. Reference ranges for the interpretation of the glucose tolerance test in pregnancy should therefore take account of the period of gestation. Arbitrary upper limits of normal (represented by the 97.5 centile) two hours after a 75 g oral glucose load are proposed at 7.5 and 9.6 mmol/l for the second and third trimesters, respectively.
对212名无提示葡萄糖不耐受的易感因素的孕妇进行了75克口服葡萄糖耐量试验，以确定孕期葡萄糖代谢的正常模式。在妊娠中期（14 - 20周，n = 43）和妊娠晚期（28 - 37周，n = 168）建立了该试验的参考值。一名患有需用胰岛素治疗的糖尿病的妇女被排除在外。葡萄糖负荷后1小时和2小时采集的样本在两组之间存在统计学显著差异。因此，孕期葡萄糖耐量试验结果解读的参考范围应考虑妊娠期。建议妊娠中期和晚期口服75克葡萄糖后2小时正常上限（以第97.5百分位数表示）分别为7.5和9.6毫摩尔/升。
