Forest J C, Garrido-Russo M, Lemay A, Carrier R, Dube J L
Am J Clin Pathol. 1983 Dec;80(6):828-31. doi: 10.1093/ajcp/80.6.828.
A 100-gram oral glucose tolerance test (OGTT) was performed on a selected group of normal women at each trimester of pregnancy to establish reference values for hyperglycemia and hypoglycemia. Ninety three OGTT were performed in the first trimester, 121 in the second trimester, and 98 in the last trimester. The fasting serum glucose did not differ significantly between the trimesters. The values at 60 and 120 minutes were significantly different for the fifth, fiftieth, and ninety-fifth percentiles between each trimester of pregnancy. For the 180-minute readings, the fifth and fiftieth percentiles were not significantly different between the first and second trimester of pregnancy, but the results of the third trimester were significantly higher than those of the other trimesters. The mean fasting insulinemia remained relatively constant during pregnancy. Insulin response to OGTT increased during the progression of the pregnancy. The interpretation of the glucose tolerance tests during pregnancy, either to detect gestational diabetes or hypoglycemia, should take these physiologic changes into account.
对一组选定的正常孕妇在孕期各阶段进行了100克口服葡萄糖耐量试验（OGTT），以确定高血糖和低血糖的参考值。孕早期进行了93次OGTT，孕中期进行了121次，孕晚期进行了98次。各孕期空腹血清葡萄糖无显著差异。孕期各阶段之间，第5、第50和第95百分位数在60分钟和120分钟时的值有显著差异。对于180分钟的读数，孕早期和孕中期之间第5和第50百分位数无显著差异，但孕晚期的结果显著高于其他孕期。孕期平均空腹胰岛素血症保持相对稳定。孕期胰岛素对OGTT的反应随孕期进展而增加。孕期葡萄糖耐量试验的解读，无论是检测妊娠期糖尿病还是低血糖，都应考虑这些生理变化。
