Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), 19 Keyuan Street, Jinan 250014, China.
School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China.
Fitoterapia. 2019 Sep;137:104258. doi: 10.1016/j.fitote.2019.104258. Epub 2019 Jul 5.
Four new indole alkaloids (1-4) and twenty known compounds (5-24) were isolated from the leaves and stems, and fruits of Kopsia officinalis. Their structures were confirmed by means of spectroscopic methods. All these isolates were evaluated for their antagonizing high glucose-evoked podocyte injury activity for the first time, and compounds 5-8 showed potent activity with EC values of 3.0-12.0 μM.
从 Kopsia officinalis 的叶、茎和果实中分离得到了四个新的吲哚生物碱（1-4）和二十个已知化合物（5-24）。通过光谱方法确定了它们的结构。这些分离物均首次被评估了其拮抗高糖诱导的足细胞损伤活性，化合物 5-8 表现出较强的活性，EC 值为 3.0-12.0 μM。
