Hop Nguyen Quang, Son Ninh The
Faculty of Chemistry, Hanoi Pedagogical University 2 (HPU2) Nguyen Van Linh, Xuanhoa Phucyen Vinhphuc Vietnam.
Institute of Chemistry, Vietnam Academy of Science and Technology (VAST) 18 Hoang Quoc Viet, Caugiay Hanoi Vietnam
RSC Adv. 2022 Jul 5;12(30):19171-19208. doi: 10.1039/d2ra01791a. eCollection 2022 Jun 29.
belongs to the family Apocynaceae, which was originally classified as a genus in 1823. consists of medicinal plants that can be traditionally used to treat rheumatoid arthritis, pharyngitis, tonsillitis, and dropsy. More than one hundred and twenty-five publications have been documented relating to the phytochemical and pharmacological results, but a systematic review is not available. The goal of this study is to compile almost all of the secondary metabolites from the plants of genus , as well as the coverage of their pharmacological research. The document findings were conducted reliable sources, including Web of Science, Sci-Finder, Science Direct, PubMed, Google Scholar, and publishers, while four words "", "monoterpene alkaloids", "Phytochemistry" and "Pharmacology" are key factors to search for references. Most secondary metabolites were collected. A total of four hundred and seventy-two, including four hundred and sixty-six monoterpene alkaloids, five triterpenoids, and one sterol, were summarized, along with their resource. monoterpene alkaloids presented in various skeletons, but aspidofractinines, eburnamines, and chanofruticosinates are the three major backbones. Mersinines and pauciflorines are new chemical classes of monoterpene alkaloids. With the rich content of monoterpene alkaloids, constituents were also the main objects in pharmacological studies since the plant extracts and isolated compounds were proposed for anti-microbial, anti-inflammatory, anti-allergic, anti-diabetic, anti-manic, anti-nociceptive, acetylcholinesterase (AChE) inhibitory, cardiovascular, and vasorelaxant activities, especially cytotoxicity.
属于夹竹桃科，该科于1823年最初被归类为一个属。由传统上可用于治疗类风湿性关节炎、咽炎、扁桃体炎和水肿的药用植物组成。已经有超过125篇关于植物化学和药理学结果的文献记载，但尚无系统综述。本研究的目的是汇编该属植物几乎所有的次生代谢产物，以及它们药理学研究的涵盖范围。文献检索是通过可靠来源进行的，包括科学网、科学发现者、科学Direct、PubMed、谷歌学术和出版商，而“”、“单萜生物碱”、“植物化学”和“药理学”这四个词是搜索参考文献的关键因素。收集了大多数次生代谢产物。总共总结了472种，包括466种单萜生物碱、5种三萜类化合物和1种甾醇，并列出了它们的来源。单萜生物碱呈现出各种骨架，但阿朴菲宁类、依波宁类和查诺弗鲁蒂辛类是三大主要骨架。美辛类和少花类是单萜生物碱的新化学类别。由于该属植物的单萜生物碱含量丰富，其成分也是药理学研究的主要对象，因为植物提取物和分离出的化合物被认为具有抗菌、抗炎、抗过敏、抗糖尿病、抗躁狂、抗伤害感受、乙酰胆碱酯酶（AChE）抑制、心血管和血管舒张活性，尤其是细胞毒性。
