College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea.
College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu 41566, Republic of Korea.
Fitoterapia. 2019 Sep;137:104261. doi: 10.1016/j.fitote.2019.104261. Epub 2019 Jul 5.
Three new sesquilignans, zijusesquilignans A-C (1-3), together with fifteen known compounds (4-18), were isolated from fruits of Ziziphus jujuba var. inermis Rehder (Rhamnaceae). Their chemical structures were established using spectroscopic analyses including 1D- and 2D-NMR, HR-EIMS, and ECD spectra. These compounds were assessed for their inhibitory effects on nitric oxide (NO) production. Of these compounds, 1-3 and 17 displayed inhibitory effects on NO production, with IC values ranging from 18.1 to 66.4 μM. Pretreatment with 1 and 17 significantly suppressed LPS-induced expression of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein in cells. Moreover, compounds 1-3, 7, 9, and 17 exhibited cytotoxic activities against three human tumor cell lines, with IC values ranging from 8.4 to 44.9 μM.
从无刺枣（Rhamnaceae）果实中分离得到了三个新的倍半木脂素，即紫穗槐倍半木脂素 A-C（1-3），以及十五个已知化合物（4-18）。通过包括 1D 和 2D-NMR、HR-EIMS 和 ECD 光谱在内的光谱分析确定了它们的化学结构。评估了这些化合物对一氧化氮（NO）生成的抑制作用。其中，化合物 1-3 和 17 对 NO 生成表现出抑制作用，IC 值范围为 18.1-66.4μM。1 和 17 的预处理显著抑制了 LPS 诱导的细胞中一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）蛋白的表达。此外，化合物 1-3、7、9 和 17 对三种人肿瘤细胞系表现出细胞毒性活性，IC 值范围为 8.4-44.9μM。
