圆叶牡荆果实中的抗炎成分。
Anti-inflammatory constituents from the fruits of Vitex rotundifolia.
机构信息
College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
出版信息
Bioorg Med Chem Lett. 2013 Nov 1;23(21):6010-4. doi: 10.1016/j.bmcl.2013.08.004. Epub 2013 Aug 9.
Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3 to 24.5μM.
从三叶木通的果实中分离得到三个新的二萜（7、15 和 17）和两个新的新木脂素（19 和 20）以及十九个已知化合物。通过 1D 和 2D NMR、HRESI-MS 和 CD 数据的组合，阐明了它们的结构。所有分离物均测试了其对 LPS 诱导的 RAW264.7 细胞中一氧化氮产生的抑制活性。其中，化合物 3、4、7、13、15、19 和 24 发现对一氧化氮的产生具有抑制作用，IC50 值范围为 11.3 至 24.5μM。
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