Laboratoire PEIRENE, Faculté de Pharmacie, Université de Limoges, EA 7500, F-87025 Limoges, France.
Institut de Chimie, Université de Neuchâtel, Avenue de Bellevaux 51, CH-2000 Neuchâtel, Switzerland.
Int J Mol Sci. 2019 Jul 7;20(13):3339. doi: 10.3390/ijms20133339.
Photodynamic Therapy (PDT) has become one of the most promising treatment against autoimmune diseases, such as rheumatoid arthritis (RA), as well as in the treatment of different types of cancer, since it is a non-invasive method and easy to carry out. The three main ingredients of PDT are light irradiation, oxygen, and a photosensitizer (PS). Light irradiation depends on the type of molecule or compound to be used as a PS. The concentration of O fluctuates according to the medium where the target tissue is located and over time, although it is known that it is possible to provide oxygenated species to the treated area through the PS itself. Finally, each PS has its own characteristics, the efficacy of which depends on multiple factors, such as solubility, administration technique, retention time, stability, excitation wavelength, biocompatibility, and clearance, among others. Therefore, it is essential to have a thorough knowledge of the disease to select the best PS for a specific target, such as RA. In this review we will present the PSs used in the last three decades to treat RA under PDT protocol, as well as insights on the relevant strategies.
光动力疗法 (PDT) 已成为治疗自身免疫性疾病（如类风湿关节炎 (RA)）以及治疗不同类型癌症的最有前途的方法之一，因为它是一种非侵入性的方法，易于实施。PDT 的三个主要成分是光照射、氧气和光敏剂 (PS)。光照射取决于将用作 PS 的分子或化合物的类型。O 的浓度根据目标组织所在的介质而波动，并且随着时间的推移而波动，尽管已知可以通过 PS 本身向治疗区域提供含氧物质。最后，每种 PS 都有其自身的特点，其功效取决于多种因素，例如溶解度、给药技术、保留时间、稳定性、激发波长、生物相容性和清除率等。因此，深入了解疾病对于选择针对特定目标（如 RA）的最佳 PS 至关重要。在本次综述中，我们将介绍过去三十年中用于 RA 的 PDT 方案的 PS 以及相关策略的见解。
Zotero 插件