Xiao Qicai, Wu Juan, Pang Xin, Jiang Yue, Wang Pan, Leung Albert W, Gao Liqian, Jiang Sheng, Xu Chuanshan
School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, 135 Xingang Xi Road, Guangzhou, 510275, China.
School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Curr Med Chem. 2018;25(7):839-860. doi: 10.2174/0929867324666170823143137.
Photodynamic therapy (PDT) has been developed as an alternative modality for the management of neoplastic and nonneoplastic diseases. It is a minimally invasive treatment that involves the interaction of a non-toxic photosensitizer (PS), light and molecular oxygen to generate reactive oxygen species (ROS), resulting in the destruction of unwanted cells and tissues. Discovery and development of new PSs with optimized properties are much crucial for achieving a desirable therapeutic efficacy. This review describes the photochemical and photobiological mechanisms of PDT, and outlines the recent progress in discovery and development of natural products and their derivatives as phototherapeutic drugs. The potential limitations and future perspectives of PDT in clinical application are also presented and discussed.
光动力疗法（PDT）已被开发成为一种用于治疗肿瘤性和非肿瘤性疾病的替代方法。它是一种微创治疗，涉及无毒光敏剂（PS）、光和分子氧之间的相互作用，以产生活性氧（ROS），从而导致不需要的细胞和组织被破坏。发现并开发具有优化特性的新型光敏剂对于实现理想的治疗效果至关重要。本文综述了光动力疗法的光化学和光生物学机制，并概述了天然产物及其衍生物作为光疗药物在发现和开发方面的最新进展。还介绍并讨论了光动力疗法在临床应用中的潜在局限性和未来前景。
