Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Chem Commun (Camb). 2019 Feb 26;55(18):2676-2679. doi: 10.1039/c8cc09186b.
Three chloromethyl-modified Ru(ii) complexes were designed and synthesized as mitochondria targeting photosensitizers, which can generate carbon radicals in the presence of NADH under visible light irradiation, cause DNA cleavage and covalent binding in Ar-saturated solutions, and lead to apoptosis of human ovarian carcinoma SKOV-3 cells under hypoxic conditions (3% O2), demonstrating a new mode of type I mechanism to overcome the limitation of hypoxia in photodynamic therapy (PDT).
三种氯甲基化的 Ru(ii) 配合物被设计并合成作为线粒体靶向光敏剂，它们可以在可见光照射下、有 NADH 存在的条件下产生碳自由基，在 Ar 饱和溶液中引起 DNA 断裂和共价结合，并在低氧条件（3% O2）下导致人卵巢癌细胞 SKOV-3 凋亡，这展示了一种克服光动力疗法（PDT）中缺氧限制的 I 型机制的新模式。
