Ito S, Tsuji Y, Kitagawa N, Akihiko I, Syundo J, Tamura Y, Kishi S, Mori H
Second Department of Internal Medicine, School of Medicine, University of Tokushima, Kuramoto Cho, Japan.
Hepatology. 1988 Mar-Apr;8(2):383-4. doi: 10.1002/hep.1840080233.
We adopted an automated method for measuring guanase in donor blood and examined the incidence of posttransfusional non-A, non-B hepatitis when donor blood with high guanase activities was excluded. Sixty-seven (2.4%) of 2,826 units were excluded from use in transfusion because they had guanase activities above 1.71 units per liter. Of 112 recipients, 8 (7%) developed posttransfusional non-A, non-B hepatitis. The incidence of posttransfusional non-A, non-B hepatitis was 17% before adoption of the guanase screening test and 7% after its adoption. Thus, the incidence of posttransfusional non-A, non-B hepatitis was significantly decreased after adoption of this screening test. This study shows that, for prevention of posttransfusional non-A, non-B hepatitis, it is important to screen donor blood for guanase activity and discard blood with high activities.
我们采用了一种自动方法来检测供血中的鸟嘌呤酶，并在排除鸟嘌呤酶活性高的供血后，检查了输血后非甲非乙型肝炎的发生率。2826单位供血中有67单位（2.4%）因鸟嘌呤酶活性高于每升1.71单位而被排除用于输血。在112名受血者中，8名（7%）发生了输血后非甲非乙型肝炎。在采用鸟嘌呤酶筛查试验之前，输血后非甲非乙型肝炎的发生率为17%，采用后为7%。因此，采用该筛查试验后，输血后非甲非乙型肝炎的发生率显著降低。这项研究表明，为预防输血后非甲非乙型肝炎，对供血进行鸟嘌呤酶活性筛查并丢弃活性高的血液很重要。
