Wittawatmongkol Orasri, Gatechompol Sivaporn, Kerr Stephen J, Chalermchockcharoenkit Amphan, Teeratakulpisarn Nipat, Lermankul Watcharee, Thamkhantho Manopchai, Phanuphak Nittaya, Sohn Annette H, Chokephaibulkit Kulkanya
1 Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
2 HIV-NAT, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Int J STD AIDS. 2019 Sep;30(10):960-968. doi: 10.1177/0956462419853384. Epub 2019 Jul 8.
HIV infection may increase the risk of persistent infection and complications. Perinatally HIV-infected (PHIV) and HIV-uninfected male adolescents and young adults (AYA) in Thailand were matched by age and number of lifetime sexual partners. HPV infection at oral, anal, penile, and scrotal sites was detected by polymerase chain reaction. A total of 49 PHIV and 47 HIV-uninfected male AYA (median age 18 [17–20] years) were enrolled (June 2013– September 2014). Overall, 18 were men who had sex with men (MSM) (12% of PHIV and 26% of HIV-uninfected AYA; =0.12). Among the PHIV, the median (IQR) CD4 cell count was 573 (434–747) cells/mm and 69% had HIV RNA load <40 copies/mL. The prevalence of any HPV infection was 61% in PHIV and 49% in HIV-uninfected AYA (=0.23); and that of high-risk HPV infection was 33% in PHIV and 28% in HIV-uninfected AYA (=0.59). Among those with HPV, 55% were infected with any high-risk HPV type and 28% had HPV-16 and/or HPV-18. In multivariate models, smoking (OR 6.10, 95% CI, 1.19–31.35, =0.01) and prior history of STI symptoms (OR 5.01, 95% CI, 1.63–15.40, =0.004) were associated with high-risk HPV infection. HPV vaccination in early adolescence presents a valuable but missed prevention opportunity.
艾滋病毒感染可能会增加持续感染和并发症的风险。在泰国，按年龄和终身性伴侣数量对围产期感染艾滋病毒（PHIV）的男性青少年和青年（AYA）以及未感染艾滋病毒的男性青少年和青年进行了匹配。通过聚合酶链反应检测口腔、肛门、阴茎和阴囊部位的人乳头瘤病毒（HPV）感染情况。共招募了49名感染艾滋病毒的男性青少年和青年以及47名未感染艾滋病毒的男性青少年和青年（中位年龄18岁[17 - 20岁]）（2013年6月至2014年9月）。总体而言，18人为男男性行为者（MSM）（占感染艾滋病毒者的12%，未感染艾滋病毒者的26%；P = 0.12）。在感染艾滋病毒者中，CD4细胞计数的中位数（IQR）为573（434 - 747）个细胞/mm³，69%的人艾滋病毒RNA载量<40拷贝/mL。任何HPV感染的患病率在感染艾滋病毒者中为61%，在未感染艾滋病毒者中为49%（P = 0.23）；高危HPV感染的患病率在感染艾滋病毒者中为33%，在未感染艾滋病毒者中为28%（P = 0.59）。在感染HPV的人群中，55%感染了任何高危HPV类型，28%感染了HPV - 十六型和/或HPV - 十八型。在多变量模型中，吸烟（比值比6.10，95%置信区间，1.19 - 31.35，P = 0.01）和性传播感染症状既往史（比值比5.01，95%置信区间，1.63 - 15.40，P = 0.004）与高危HPV感染相关。青春期早期接种HPV疫苗是一个有价值但被错过的预防机会。
