Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Way, 4059 BSRB, Ann Arbor, MI 48109-2200, USA.
Mary H. Weiser Food Allergy Center, University of Michigan Medical School, 109 Zina Pitcher Way, 4059 BSRB, Ann Arbor, MI 48109-2200, USA.
Immunol Allergy Clin North Am. 2019 Aug;39(3):309-319. doi: 10.1016/j.iac.2019.03.002. Epub 2019 Apr 30.
The infant's developing immune response is central to establishing a balanced system that reacts appropriately to infectious stimuli, but does not induce altered disease states with potential long-term sequelae. Respiratory syncytial virus may alter the immune system, affecting future responses. Early infection may have direct effects on the lung itself. Other early life processes contribute to the development of immune responses including assembly of the microbiome, which seems to have a particularly important role for establishing the immune environment. This review covers studies that have set up important paradigms and discusses recent data that direct research toward informative hypotheses.
婴儿不断发育的免疫反应对于建立一个平衡的系统至关重要，该系统可以对感染性刺激做出适当反应，但不会引起可能产生长期后遗症的改变疾病状态。呼吸道合胞病毒可能会改变免疫系统，影响未来的反应。早期感染可能会对肺部本身产生直接影响。其他生命早期过程也有助于免疫反应的发展，包括微生物组的组装，这对于建立免疫环境似乎具有特别重要的作用。本综述涵盖了建立重要范例的研究，并讨论了指导研究形成有意义假说的最新数据。
