Gan Lidan, Liu Enmei, Deng Yu
Department of Respiratory Medicine Children's Hospital of Chongqing Medical University Chongqing China.
Ministry of Education Key Laboratory of Child Development and Disorders Children's Medical Big Data Intelligent Application Center Department of Respiratory Medicine Chongqing China.
Pediatr Discov. 2024 Jul 16;2(4):e97. doi: 10.1002/pdi3.97. eCollection 2024 Dec.
Respiratory syncytial virus (RSV) is an essential cause of lower respiratory tract infection in children under 2 years of age, especially under 6 months. In decades, studies have shown that the respiratory tract microflorae with RSV infection were related to disease severity and played a role in the development of recurrent wheezing, but the effect of respiratory microflorae on RSV infection are still underestimated. This study aims to conclude the effect of respiratory microflorae colonization on RSV infectious disease severity and recurrent wheezing and provide suggestions for future research directions from the perspective of respiratory tract florae. We conducted a scoping review. Studies were eligible if they reported on the effect of microflorae on RSV infectious diseases among children. We exacted the following information: title, publication time, first author's country, and article type. We finally included 33 articles in this scoping review. The number of studies rapidly increased since 2013 and the highest number of hospitalizations were reported in children <2 years. More than half (69.70%) were conducted in America and most studies are original studies (57.58%). The Review highlighted that the respiratory microflorae played an important role in RSV infectious disease severity and recurrent wheezing. We found that (S.pn), (HI), (M.ca), and (SA) were the dominant profiles in children with RSV infection. Understanding the respective role of respiratory microflorae on RSV infection and its mechanisms would improve prevention and treatment strategies from the perspective of microflorae.
呼吸道合胞病毒（RSV）是2岁以下儿童，尤其是6个月以下儿童下呼吸道感染的重要病因。几十年来，研究表明，RSV感染时的呼吸道微生物群与疾病严重程度相关，并在复发性喘息的发展中起作用，但呼吸道微生物群对RSV感染的影响仍被低估。本研究旨在总结呼吸道微生物群定植对RSV感染性疾病严重程度和复发性喘息的影响，并从呼吸道菌群的角度为未来的研究方向提供建议。我们进行了一项范围综述。如果研究报告了微生物群对儿童RSV感染性疾病的影响，则该研究符合纳入标准。我们提取了以下信息：标题、发表时间、第一作者所在国家和文章类型。我们最终在本范围综述中纳入了33篇文章。自2013年以来，研究数量迅速增加，2岁以下儿童的住院人数报告最多。超过一半（69.70%）的研究在美国进行，大多数研究是原创研究（57.58%）。该综述强调，呼吸道微生物群在RSV感染性疾病严重程度和复发性喘息中起重要作用。我们发现，肺炎链球菌（S.pn）、流感嗜血杆菌（HI）、卡他莫拉菌（M.ca）和金黄色葡萄球菌（SA）是RSV感染儿童中的主要菌群。了解呼吸道微生物群对RSV感染的各自作用及其机制将从微生物群的角度改善预防和治疗策略。
