Zaleski M B, Gorzynski T
J Immunol. 1979 May;122(5):2074-6.
An effective anti-Thy-1 response requires at least three conditions to be simultaneously fulfilled--1) The responder has to share an H-2 haplotype, or at least K and D alleles, with the donor of the Thy-1 disparate thymocytes, 2) The responder has to differ from the donor by some non-H-2 cell-surface antigens, and 3) The responder has to possess functionally capable T cells. All these requirements are consistent with the hypothesis that Thy-1 antigens and the non-H-2 antigen(s), the latter serving as carrier, form a complex that is viewed as a variant of self and then recognized in the context of the H-2 molecules by the responder's T cells. An attractive feature of the proposed hypothesis is that it could be applicable to a variety of cell-surface and also exogenous antigens.
有效的抗Thy-1反应至少需要同时满足三个条件：1）应答者必须与Thy-1不同的胸腺细胞供体共享一个H-2单倍型，或至少共享K和D等位基因；2）应答者必须在某些非H-2细胞表面抗原上与供体不同；3）应答者必须拥有功能正常的T细胞。所有这些要求都与以下假设一致：Thy-1抗原和作为载体的非H-2抗原形成一种复合物，该复合物被视为自身变体，然后被应答者的T细胞在H-2分子的背景下识别。所提出假设的一个吸引人的特点是，它可能适用于多种细胞表面抗原以及外源性抗原。
