Bromberg J S, Lake P, Brunswick M
J Immunol. 1982 Aug;129(2):683-8.
Thy-1 alloantigens on murine thymus cells are weak immunogens in vivo for PFC responses in the absence of other antigenic disparities between the donor and recipient. Our previous work showed that non-H-2 alloantigens acted as helper determinants to augment anti-Thy-1 PFC responses. In this report we demonstrate that strong helper antigens are also produced by infection of donor thymus cells with viruses such as HSV-1, NDV, or vaccinia. This helper effect (as much as 30-fold) for a cellular antigen, requires linked recognition (expression of Thy-1 and virus in the same cell membrane), is T-dependent, antigen- (virus) specific, and is Thy-1-specific. The recognition of the viral helper sites is not restricted by the MHC genotype of the thymus cell donor, indicating that host reprocessing of antigen occurs. These are the first results that show that adventitious antigens may function as helper determinants for antibody responses to native membrane antigens and may be the mechanism that initiates several forms of acute post-viral autoimmune disease.
在供体和受体之间不存在其他抗原差异的情况下，小鼠胸腺细胞上的Thy-1同种异体抗原在体内对于PFC反应而言是弱免疫原。我们之前的研究表明，非H-2同种异体抗原作为辅助决定簇可增强抗Thy-1的PFC反应。在本报告中，我们证明，用诸如单纯疱疹病毒1型（HSV-1）、新城疫病毒（NDV）或痘苗病毒等病毒感染供体胸腺细胞也会产生强辅助抗原。这种针对细胞抗原的辅助效应（高达30倍）需要连锁识别（Thy-1和病毒在同一细胞膜上表达），是T细胞依赖性的、抗原（病毒）特异性的且是Thy-1特异性的。对病毒辅助位点的识别不受胸腺细胞供体的MHC基因型限制，这表明发生了抗原的宿主再加工。这些是首次表明外来抗原可能作为针对天然膜抗原的抗体反应的辅助决定簇发挥作用，并且可能是引发几种急性病毒后自身免疫性疾病的机制的结果。
