McGoldrick Leif K, Weiss Elizabeth A, Halámek Jan
Department of Chemistry , University at Albany, State University of New York , 1400 Washington Avenue , Albany , New York 12222 , United States.
ACS Synth Biol. 2019 Jul 19;8(7):1655-1662. doi: 10.1021/acssynbio.9b00164. Epub 2019 Jul 9.
The research presented here shows a bridge between biochemistry and cryptography. Enzyme-based assays were used in a new methodology linked to ciphers and cipher systems. Three separate enzyme assays, alkaline phosphatase (ALP) (E.C. 3.1.3.1), lysozyme (E.C. 3.2.1.17), and horseradish peroxidase (HRP) (E.C. 1.11.1.7), were used to create a cipher key in order to encrypt a message. By choosing certain parameters for one's experiment that are performed in the same way as a person receiving the message, correct encryption and decryption keys would be produced, resulting in a correct encryption and decryption of a message. It is imperative that both parties perform the same experiment under the same conditions in order to correctly interpret the message. Bioaffinity-based assays, in particular enzymatic assays, provide a specific, yet flexible mechanism to use for the encryption of messages. Because of the nature of this process there are a multitude of sets of parameters that may be chosen, each of which would result in a different key being produced, heightening the security and the robustness of the method. This paper shows that by using this concept of forming encryption keys using a bioaffinity-based approach, one is able to properly encrypt and decrypt a message, which could be viable for other biochemically based techniques.
此处展示的研究成果搭建了一座生物化学与密码学之间的桥梁。基于酶的分析方法被应用于一种与密码和密码系统相关的新方法中。三种独立的酶分析方法，即碱性磷酸酶（ALP）（酶学委员会编号3.1.3.1）、溶菌酶（酶学委员会编号3.2.1.17）和辣根过氧化物酶（HRP）（酶学委员会编号1.11.1.7），被用于生成一个密码密钥以加密一条信息。通过为某人的实验选择某些参数，这些参数的设置方式与接收信息的人相同，就能生成正确的加密和解密密钥，从而实现对信息的正确加密和解密。双方必须在相同条件下进行相同的实验，以便正确解读信息。基于生物亲和力的分析方法，尤其是酶分析方法，为信息加密提供了一种特定且灵活的机制。由于这个过程的性质，可以选择众多组参数，每组参数都会产生不同的密钥，从而提高了该方法的安全性和稳健性。本文表明，通过使用这种基于生物亲和力的方法来形成加密密钥的概念，能够对信息进行正确的加密和解密，这对于其他基于生物化学的技术可能是可行的。
