通过与氯酚盐抗衡阴离子形成离子对来决定DNA“光开关”钌（II）-多吡啶配合物在活细胞中优先核摄取的主要物理化学因素有哪些？
What Are the Major Physicochemical Factors in Determining the Preferential Nuclear Uptake of the DNA "Light-Switching" Ru(II)-Polypyridyl Complex in Live Cells via Ion-Pairing with Chlorophenolate Counter-Anions?
作者信息
Huang Rong, Tang Miao, Huang Chun-Hua, Chao Xi-Juan, Yan Zhu-Ying, Shao Jie, Zhu Ben-Zhan
机构信息
State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research Center for Eco-Environmental Sciences, and University of Chinese Academy of Sciences, Chinese Academy of Sciences , Beijing 100085 , People's Republic of China.
School of Life Sciences , Lanzhou University , Lanzhou 730000 , People's Republic of China.
出版信息
J Phys Chem Lett. 2019 Jul 18;10(14):4123-4128. doi: 10.1021/acs.jpclett.9b01225. Epub 2019 Jul 9.
Delivering potential theranostic metal complexes into preferential cellular targets is becoming of increasing interest. Here we report that nuclear uptake of a cell-impermeable DNA "light-switching" Ru(II)-polypyridyl complex can be significantly facilitated by chlorophenolate counter-anions, which was found, unexpectedly, to be correlated positively with the binding stability but inversely with the lipophilicity of the formed ion pairs.
将潜在的诊疗金属配合物递送至特定的细胞靶点正变得越来越受关注。在此，我们报告，一种细胞不可渗透的DNA“光开关”钌（II）-多吡啶配合物的核摄取可被氯酚盐抗衡阴离子显著促进，出乎意料的是，这被发现与形成的离子对的结合稳定性呈正相关，但与亲脂性呈负相关。
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