Chimie ParisTech, PSL University, CNRS, Institut de Recherche de Chimie Paris, Paris, 75005, France.
Chimie ParisTech, PSL University, CNRS, Institute of Chemistry for Life and Health Sciences, Laboratory for Inorganic Chemical Biology, Paris, 75005, France.
Adv Mater. 2020 Nov;32(47):e2003294. doi: 10.1002/adma.202003294. Epub 2020 Oct 19.
Ru(II) polypyridyl complexes are compounds of great interest in cancer therapy due to their unique photophysical, photochemical, and biological properties. For effective treatment, they must be able to penetrate tumor cells effectively and selectively. The development of nanoscale carriers capable of delivering Ru(II) polypyridyl complexes has the potential to passively or selectively enhance their cellular uptake in tumor cells. Many different strategies have been explored to incorporate Ru(II) polypyridyl complexes into a variety of nanosized constructs, ranging from organic to inorganic materials. Herein, recent developments in nanomaterials loaded with Ru(II) polypyridyl complexes are highlighted. Their rational design, preparation, and physicochemical properties are described, and their potential applications in cancer therapy are eventually discussed.
钌（II）多吡啶配合物由于其独特的光物理、光化学和生物学特性，在癌症治疗中具有重要的应用价值。为了达到有效的治疗效果，它们必须能够有效地穿透肿瘤细胞并具有选择性。开发能够递送钌（II）多吡啶配合物的纳米载体，具有被动或选择性增强其在肿瘤细胞中的摄取的潜力。已经探索了许多不同的策略来将钌（II）多吡啶配合物整合到各种纳米结构中，包括有机到无机材料。本文重点介绍了负载钌（II）多吡啶配合物的纳米材料的最新进展。描述了它们的合理设计、制备和物理化学性质，并最终讨论了它们在癌症治疗中的潜在应用。
