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猪源 H1N1 犬流感病毒的特征。

Characterization of swine-origin H1N1 canine influenza viruses.

机构信息

a The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences , Inner Mongolia University , Hohhot , People's Republic of China.

b Department of Microbiology , Icahn School of Medicine at Mount Sinai , New York , USA.

出版信息

Emerg Microbes Infect. 2019;8(1):1017-1026. doi: 10.1080/22221751.2019.1637284.

DOI:10.1080/22221751.2019.1637284
PMID:31287780
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7011970/
Abstract

Host switch events of influenza A viruses (IAVs) continuously pose a zoonotic threat to humans. In 2013, swine-origin H1N1 IAVs emerged in dogs soon after they were detected in swine in the Guangxi province of China. This host switch was followed by multiple reassortment events between these H1N1 and previously circulating H3N2 canine IAVs (IAVs-C) in dogs. To evaluate the phenotype of these newly identified viruses, we characterized three swine-origin H1N1 IAVs-C and one reassortant H1N1 IAV-C. We found that H1N1 IAVs-C predominantly bound to human-type receptors, efficiently transmitted via direct contact in guinea pigs and replicated in human lung cells. Moreover, the swine-origin H1N1 IAVs-C were lethal in mice and were transmissible by respiratory droplets in guinea pigs. Importantly, sporadic human infections with these viruses have been detected, and preexisting immunity in humans might not be sufficient to prevent infections with these new viruses. Our results show the potential of H1N1 IAVs-C to infect and transmit in humans, suggesting that these viruses should be closely monitored in the future.

摘要

流感 A 病毒（IAVs）的宿主转换事件持续对人类构成动物源性威胁。2013 年，在中国广西省猪中检测到猪源 H1N1 IAV 后，猪源 H1N1 IAV 很快出现在犬中。这一宿主转换之后，这些 H1N1 和之前在犬中循环的 H3N2 犬源 IAV（IAVs-C）之间发生了多次重配事件。为了评估这些新鉴定的病毒的表型，我们对三种猪源 H1N1 IAV-C 和一种重配的 H1N1 IAV-C 进行了特征描述。我们发现 H1N1 IAV-C 主要结合人类型受体，能够通过豚鼠的直接接触有效传播，并在人肺细胞中复制。此外，猪源 H1N1 IAV-C 在小鼠中具有致死性，能够通过豚鼠的飞沫传播。重要的是，已经检测到这些病毒的散发性人类感染，而且人类预先存在的免疫可能不足以预防这些新病毒的感染。我们的研究结果表明，H1N1 IAV-C 有在人类中感染和传播的潜力，这表明这些病毒在未来应密切监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/da8fa4d0a7d8/TEMI_A_1637284_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/1a9679f3a289/TEMI_A_1637284_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/95e0f57299d5/TEMI_A_1637284_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/bb6a58c0ee3b/TEMI_A_1637284_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/9b0ee8dd70bf/TEMI_A_1637284_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/b0ae5f6ce728/TEMI_A_1637284_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/da8fa4d0a7d8/TEMI_A_1637284_F0006_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/1a9679f3a289/TEMI_A_1637284_F0001_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/95e0f57299d5/TEMI_A_1637284_F0002_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/bb6a58c0ee3b/TEMI_A_1637284_F0003_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/9b0ee8dd70bf/TEMI_A_1637284_F0004_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/b0ae5f6ce728/TEMI_A_1637284_F0005_OC.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3f/7011970/da8fa4d0a7d8/TEMI_A_1637284_F0006_OC.jpg

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本文引用的文献

[1]
In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit.

Antiviral Res. 2018-10-11

[2]
Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings.

Clin Drug Investig. 2018-12

[3]
Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil.

Sci Rep. 2018-6-25

[4]
Emergence and Evolution of Novel Reassortant Influenza A Viruses in Canines in Southern China.

mBio. 2018-6-5

[5]
Emergence of Eurasian Avian-Like Swine Influenza A (H1N1) Virus from an Adult Case in Fujian Province, China.

Virol Sin. 2018-6

[6]
Novel triple-reassortant influenza viruses in pigs, Guangxi, China.

Emerg Microbes Infect. 2018-5-16

[7]
NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?

mBio. 2018-4-3

[8]
H7N9 virulent mutants detected in chickens in China pose an increased threat to humans.

Cell Res. 2017-10-24

[9]
Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States.

J Infect Dis. 2017-9-15

[10]
Spread of Canine Influenza A(H3N2) Virus, United States.

Emerg Infect Dis. 2017-12-17

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