Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 1UL, United Kingdom.
Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh PA 15261, USA.
Curr Opin Microbiol. 2019 Dec;52:100-109. doi: 10.1016/j.mib.2019.06.002. Epub 2019 Jul 6.
Candidalysin is a cytolytic peptide toxin secreted by the invasive form of the human pathogenic fungus, Candida albicans. Candidalysin is critical for mucosal and systemic infections and is a key driver of host cell activation, neutrophil recruitment and Type 17 immunity. Candidalysin is regarded as the first true classical virulence factor of C. albicans but also triggers protective immune responses. This review will discuss how candidalysin was discovered, the mechanisms by which this peptide toxin contributes to C. albicans infections, and how its discovery has advanced our understanding of fungal pathogenesis and disease.
念珠菌溶素是一种细胞溶解肽毒素，由人类致病性真菌白念珠菌的侵袭形式分泌。念珠菌溶素对于粘膜和全身感染至关重要，是宿主细胞激活、中性粒细胞募集和 17 型免疫的关键驱动因素。念珠菌溶素被认为是白念珠菌的第一个真正的经典毒力因子，但也引发了保护性免疫反应。这篇综述将讨论念珠菌溶素是如何被发现的，这种肽毒素如何促进白念珠菌感染，以及它的发现如何促进我们对真菌发病机制和疾病的理解。
