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自闭症儿童的确诊年龄、患病率和整体健康状况:全国范围的观察性研究。

Age at identification, prevalence and general health of children with autism: observational study of a whole country population.

机构信息

Institute of Health and Wellbeing, University of Glasgow Mental Health and Wellbeing, Glasgow, UK.

Gillbergcentrum/Gillberg Neuropsychiatry Centre, Göteborgs Universitet/University of Gothenburg, Göteborg, Sweden.

出版信息

BMJ Open. 2019 Jul 9;9(7):e025904. doi: 10.1136/bmjopen-2018-025904.

Abstract

OBJECTIVES

Reported childhood prevalence of autism varies considerably between studies and over time, and general health status has been little investigated. We aimed to investigate contemporary prevalence of reported autism by age, and general health status of children/young people with and without autism.

DESIGN

Secondary analysis of Scotland's Census, 2011 data. Cross-sectional study.

SETTING

General population of Scotland.

PARTICIPANTS

All children (n=916 331) and young people (n=632 488) in Scotland.

MAIN OUTCOME MEASURES

Number (%) of children/young people reported to have autism and their general health status; prevalence of autism; prevalence of poor health (fair, bad and very bad health); odds ratios (95% confidence intervals) of autism predicting poor health, adjusted for age and gender and OR for age and gender in predicting poor health within the population with reported autism.

RESULTS

Autism was reported for 17 348/916 331 (1.9%) children aged 0-15, and 7715/632 488 (1.2%) young people aged 16-24. The rate increased to age 11 in boys and age 10 in girls, reflecting age at diagnosis. Prevalence was 2.8% at age 10 (4.4% for boys; 1.1% for girls), and 2.9% at age 11 (4.5% for boys; 1.1% for girls). 22.0% of children and 25.5% of young people with autism reported poor health, compared with 2.0% and 4.4% without autism. Autism had OR=11.3 (11.0 to 11.7) in predicting poor health. Autistic females had poorer health than autistic males, OR=1.6 (1.5 to 1.8).

CONCLUSION

Accurate information on the proportion of autistic children and their health status is essential plan appropriate prevention and intervention measures and provide resources for those who may put demand on services designed for autistic people.

摘要

目的

自闭症在不同研究和不同时间的报告儿童患病率差异很大,而一般健康状况则很少被调查。我们旨在调查按年龄报告的自闭症的当代患病率,以及自闭症儿童/青少年和非自闭症儿童/青少年的一般健康状况。

设计

苏格兰 2011 年人口普查的二次分析。横断面研究。

地点

苏格兰的普通人群。

参与者

所有儿童(n=916331 人)和青年(n=632488 人)在苏格兰。

主要观察指标

报告有自闭症的儿童/青年人数及其一般健康状况;自闭症的患病率;健康状况不佳(一般、差和非常差)的患病率;自闭症预测健康状况不佳的优势比(95%置信区间),并按年龄和性别进行调整,以及在报告有自闭症的人群中,年龄和性别对预测健康状况不佳的优势比。

结果

0-15 岁儿童中报告有自闭症的有 17348/916331(1.9%),16-24 岁青年中报告有自闭症的有 7715/632488(1.2%)。该比率在男孩中在 11 岁时和女孩中在 10 岁时上升,反映了诊断年龄。在 10 岁时的患病率为 2.8%(男孩为 4.4%;女孩为 1.1%),在 11 岁时的患病率为 2.9%(男孩为 4.5%;女孩为 1.1%)。自闭症儿童中有 22.0%报告健康状况不佳,而自闭症青年中有 25.5%报告健康状况不佳,而非自闭症儿童/青少年中则分别为 2.0%和 4.4%。自闭症预测健康状况不佳的优势比为 11.3(11.0 至 11.7)。自闭症女性的健康状况比自闭症男性差,优势比为 1.6(1.5 至 1.8)。

结论

准确了解自闭症儿童的比例及其健康状况对于计划适当的预防和干预措施以及为可能需要为自闭症患者提供服务的人提供资源至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a09/6629388/c9c4507c81bb/bmjopen-2018-025904f01.jpg

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