Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan.
Department of Nutrition, Aomori University of Health and Welfare, Aomori, Japan.
Int J Food Sci Nutr. 2020 Mar;71(2):226-234. doi: 10.1080/09637486.2019.1639638. Epub 2019 Jul 10.
Resveratrol (RSV) can protect against non-communicable diseases by improving cholesterol metabolism. However, it is unclear that effects of maternal RSV intake on health of adult offspring. In this study, we examined effects of maternal RSV intake during lactation on cholesterol metabolism in adult male rat offspring. Female Wistar rats were fed a control diet (CON) supplemented with or without RSV (20 mg/kg body weight/day) during their lactation period. Male offspring were weaned onto a standard diet and maintained on this diet for 36 weeks. As a result, plasma cholesterol level significantly decreased in RSV offspring compared to CON offspring. Furthermore, a decrease in hepatic 3-hydroxy-3-methylglutaryl-CoA reductase level and an increase in hepatic LDL-receptor level were observed in the RSV offspring. These results indicate that maternal RSV intake causes long-term decrease in plasma cholesterol level in the offspring through suppression of hepatic cholesterol biosynthesis and promotion of hepatic cholesterol uptake.
白藜芦醇 (RSV) 通过改善胆固醇代谢来预防非传染性疾病。然而，尚不清楚母体 RSV 摄入对成年后代健康的影响。在这项研究中，我们研究了哺乳期母体 RSV 摄入对成年雄性大鼠后代胆固醇代谢的影响。雌性 Wistar 大鼠在哺乳期接受对照饮食 (CON) 或补充 RSV（20mg/kg 体重/天）。雄性后代断奶后继续食用标准饮食，并维持 36 周。结果显示，与 CON 组相比，RSV 组的血浆胆固醇水平显著降低。此外，在 RSV 组还观察到肝 3-羟-3-甲基戊二酰辅酶 A 还原酶水平降低和肝 LDL 受体水平升高。这些结果表明，母体 RSV 摄入通过抑制肝内胆固醇生物合成和促进肝内胆固醇摄取，导致后代血浆胆固醇水平长期降低。
