俄罗斯首次分离的耳念珠菌（Candida auris）全基因组序列。
Whole genome sequence of first Candida auris strain, isolated in Russia.
机构信息
Kashkin Research Institute of Medical Mycology, North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.
Department of Medical Microbiology, North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg, Russia.
出版信息
Med Mycol. 2020 Apr 1;58(3):414-416. doi: 10.1093/mmy/myz078.
Candida auris is an emergent yeast pathogen, easily transmissible between patients and with high percent of multidrug resistant strains. Here we present a draft genome sequence of the first known Russian strain of C. auris, isolated from a case of candidemia. The strain clustered within South Asian C. auris clade and seemingly represented an independent event of dissemination from the original species range. Observed fluconazole resistance was probably due to F105L and K143R mutations in ERG11.
耳念珠菌是一种新兴的酵母病原体，在患者之间具有很强的传染性，且有很高比例的耐多药菌株。在这里，我们报道了首例俄罗斯耳念珠菌分离株的基因组草图，该菌是从一例念珠菌血症患者中分离得到的。该分离株与南亚的耳念珠菌分支聚类，似乎代表了该物种传播范围的一个独立事件。观察到的氟康唑耐药性可能是由于 ERG11 中的 F105L 和 K143R 突变所致。
Zotero 插件