Department of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Genoa, Italy.
Microbiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Euro Surveill. 2023 Apr;28(14). doi: 10.2807/1560-7917.ES.2023.28.14.2300161.
A difficult-to-control outbreak of is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases of carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection of S639F and F635Y mutants upon prolonged exposure to caspofungin and/or anidulafungin.
意大利利古里亚大区一家大型三级保健医院正在发生一起难以控制的疫情，该疫情于 2019 年首次出现。在一项回顾性分析中，观察到 2019 年 7 月至 2022 年 12 月期间有 503 例 携带或感染病例。基因组监测确定了一些假定病例，这些病例不再是一个明确的疫情的一部分，并且在长时间接触卡泊芬净和/或阿尼芬净后，S639F 和 F635Y 突变体的独立选择导致棘白菌素类（泛耐药）耐药性的出现。
