Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
IUBMB Life. 2019 Oct;71(10):1442-1452. doi: 10.1002/iub.2105. Epub 2019 Jul 10.
High-density lipoproteins (HDLs) are the smallest lipoprotein with the highest level of protein in their surface. The main role of HDLs are reverse transport of cholesterol from peripheral tissues to the liver. More recently, HDLs have been considered as a new drug delivery system because of their small size, proper surface properties, long circulation time, biocompatibility, biodegradability, and low immune stimulation. Delivery of anticancer drug to the tumor tissue is a major obstacle against successful chemotherapy, which is because of the toxicity and poor aqueous solubility of these drugs. Loading chemotherapeutic drugs in the lipid core of HDLs can overcome the aforementioned problems and increase the efficiency of drug delivery. In this review, we discuss the use of HDLs particles in drug delivery to the tumor tissue and explain some barriers and limitations that exist in the use of HDLs as an ideal delivery vehicle.
高密度脂蛋白 (HDL) 是脂蛋白中最小的一种，其表面蛋白含量最高。HDL 的主要作用是将胆固醇从外周组织逆转运至肝脏。最近，由于其体积小、表面性质适当、循环时间长、生物相容性、可生物降解性和低免疫刺激性，HDLs 被认为是一种新的药物传递系统。将抗癌药物递送到肿瘤组织是化疗成功的主要障碍，这是因为这些药物的毒性和较差的水溶性。将化疗药物载入 HDL 的脂质核心可以克服上述问题，并提高药物递送的效率。在这篇综述中，我们讨论了使用 HDL 颗粒将药物递送到肿瘤组织，并解释了将 HDL 作为理想的递药载体存在的一些障碍和限制。
