• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脑靶向鼻腔递送达泊酚与脑靶向鼻腔递送达泊酚和乳铁蛋白共修饰纳米粒治疗帕金森病。

Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease.

机构信息

a School of Pharmacy, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education , Yantai University , Yantai , China.

b State Key Laboratory of Long-Acting and Targeting Drug Delivery System , Shandong Luye Pharmaceutical Co., Ltd , Yantai , China.

出版信息

Drug Deliv. 2019 Dec;26(1):700-707. doi: 10.1080/10717544.2019.1636420.

DOI:10.1080/10717544.2019.1636420
PMID:31290705
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7577045/
Abstract

Efficient delivery of brain-targeted drugs is highly important for successful therapy in Parkinson's disease (PD). This study was designed to formulate borneol and lactoferrin co-modified nanoparticles (Lf-BNPs) encapsulated dopamine as a novel drug delivery system to achieve maximum therapeutic efficacy and reduce side effects for PD. Dopamine Lf-BNPs were prepared using the double emulsion solvent evaporation method and evaluated for physicochemical and pharmaceutical properties. cytotoxicity studies indicated that treatment with dopamine Lf-BNPs has relatively low cytotoxicity in SH-SY5Y and 16HBE cells. Qualitative and quantitative cellular uptake experiments indicated that Lf modification of NPs increased cellular uptake of SH-SY5Y cells and 16HBE cells, and borneol modification can promote the cellular uptake of 16HBE. pharmacokinetic studies indicated that AUC in the rat brain for dopamine Lf-BNPs was significantly higher ( < .05) than that of dopamine nanoparticles. Intranasal administration of dopamine Lf-BNPs effectively alleviated the 6-hydroxydopamine-induced striatum lesion in rats as indicated by the contralateral rotation behavior test and results for striatal monoamine neurotransmitter content detection. Taken together, intranasal administration of dopamine Lf-BNPs may be an effective drug delivery system for Parkinson's disease.

摘要

脑靶向药物的高效递送对于帕金森病（PD）的成功治疗至关重要。本研究旨在构建冰片和乳铁蛋白共修饰的载多巴胺纳米粒（Lf-BNPs）作为一种新型药物递送系统，以实现最大的治疗效果并减少 PD 的副作用。采用复乳溶剂蒸发法制备多巴胺 Lf-BNPs，并对其理化性质和药物学性质进行评价。细胞毒性研究表明，多巴胺 Lf-BNPs 对 SH-SY5Y 和 16HBE 细胞的毒性相对较低。定性和定量的细胞摄取实验表明，Lf 对 NPs 的修饰增加了 SH-SY5Y 细胞和 16HBE 细胞的摄取，而冰片修饰可以促进 16HBE 细胞的摄取。药代动力学研究表明，多巴胺 Lf-BNPs 在大鼠脑中的 AUC 明显高于多巴胺纳米粒（P <.05）。多巴胺 Lf-BNPs 的鼻腔给药通过对侧旋转行为试验和纹状体单胺神经递质含量检测结果，有效缓解了 6-羟多巴胺诱导的大鼠纹状体损伤。综上所述，多巴胺 Lf-BNPs 的鼻腔给药可能是一种有效的帕金森病药物递送系统。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/dac38f2b7a6c/IDRD_A_1636420_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/e0c5fe7535d0/IDRD_A_1636420_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/f241edb82338/IDRD_A_1636420_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/177b645cfb12/IDRD_A_1636420_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/dac38f2b7a6c/IDRD_A_1636420_F0004_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/e0c5fe7535d0/IDRD_A_1636420_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/f241edb82338/IDRD_A_1636420_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/177b645cfb12/IDRD_A_1636420_F0003_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f296/7577045/dac38f2b7a6c/IDRD_A_1636420_F0004_C.jpg

相似文献

1
Brain-targeted intranasal delivery of dopamine with borneol and lactoferrin co-modified nanoparticles for treating Parkinson's disease.脑靶向鼻腔递送达泊酚与脑靶向鼻腔递送达泊酚和乳铁蛋白共修饰纳米粒治疗帕金森病。
Drug Deliv. 2019 Dec;26(1):700-707. doi: 10.1080/10717544.2019.1636420.
2
Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson's disease treatment.用乳铁蛋白修饰的聚乙二醇-聚乳酸-羟基乙酸共聚物纳米颗粒经鼻给药将罗替戈汀输送至大脑用于帕金森病治疗
Int J Nanomedicine. 2016 Dec 7;11:6547-6559. doi: 10.2147/IJN.S120939. eCollection 2016.
3
Lactoferrin-modified rotigotine nanoparticles for enhanced nose-to-brain delivery: LESA-MS/MS-based drug biodistribution, pharmacodynamics, and neuroprotective effects.乳铁蛋白修饰的罗替戈汀纳米粒增强经鼻脑递药：基于 LESA-MS/MS 的药物体内分布、药效学和神经保护作用。
Int J Nanomedicine. 2018 Jan 9;13:273-281. doi: 10.2147/IJN.S151475. eCollection 2018.
4
Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer's disease.使用乳铁蛋白共轭的N-三甲基化壳聚糖表面修饰的聚乳酸-羟基乙酸共聚物纳米颗粒经鼻向脑递送石杉碱甲用于治疗阿尔茨海默病。
Int J Nanomedicine. 2018 Feb 1;13:705-718. doi: 10.2147/IJN.S151474. eCollection 2018.
5
Lactoferrin conjugated PEG-PLGA nanoparticles for brain delivery: preparation, characterization and efficacy in Parkinson's disease.乳铁蛋白修饰的 PEG-PLGA 纳米粒脑内递药系统的研究：制备、表征及在帕金森病模型中的药效评价。
Int J Pharm. 2011 Aug 30;415(1-2):273-83. doi: 10.1016/j.ijpharm.2011.05.062. Epub 2011 May 30.
6
Intranasal delivery of α-asarone to the brain with lactoferrin-modified mPEG-PLA nanoparticles prepared by premix membrane emulsification.采用预混膜乳化法制备乳铁蛋白修饰的 mPEG-PLA 纳米粒经鼻递送至脑内的 α-细辛脑
Drug Deliv Transl Res. 2018 Feb;8(1):83-96. doi: 10.1007/s13346-017-0438-8.
7
Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles.使用乳铁蛋白修饰的纳米颗粒对6-羟基多巴胺损伤的帕金森模型进行神经保护。
J Gene Med. 2009 Sep;11(9):754-63. doi: 10.1002/jgm.1361.
8
Design, characterization, and evaluation of intranasal delivery of ropinirole-loaded mucoadhesive nanoparticles for brain targeting.用于脑靶向的载有罗匹尼罗的粘膜粘附纳米颗粒的鼻内给药设计、表征及评价
Drug Dev Ind Pharm. 2015;41(10):1674-81. doi: 10.3109/03639045.2014.991400. Epub 2014 Dec 11.
9
Lactoferrin-modified PEG-co-PCL nanoparticles for enhanced brain delivery of NAP peptide following intranasal administration.乳铁蛋白修饰的 PEG-co-PCL 纳米粒经鼻内给药后增强 NAP 肽脑内递释
Biomaterials. 2013 May;34(15):3870-81. doi: 10.1016/j.biomaterials.2013.02.003. Epub 2013 Feb 27.
10
Selegiline Nanoformulation in Attenuation of Oxidative Stress and Upregulation of Dopamine in the Brain for the Treatment of Parkinson's Disease.用于治疗帕金森病的司来吉兰纳米制剂对脑内氧化应激的减轻及多巴胺的上调作用
Rejuvenation Res. 2018 Oct;21(5):464-476. doi: 10.1089/rej.2017.2035. Epub 2018 Jun 21.

引用本文的文献

1
The Effects of PLGA Nanoparticles Containing Different Growth Factors on Neural Stem Cell Differentiation and Their Transition Efficiency After Targeting With TRF.含不同生长因子的聚乳酸-羟基乙酸共聚物纳米颗粒对神经干细胞分化的影响及其经靶向RNA荧光原位杂交后的转变效率
CNS Neurosci Ther. 2025 Sep;31(9):e70576. doi: 10.1111/cns.70576.
2
Supramolecular Self-assembly of Tanshinone IIA to Construct an Antitumor Drug Delivery Platform.丹参酮IIA的超分子自组装构建抗肿瘤药物递送平台
ACS Omega. 2025 Aug 8;10(32):35916-35929. doi: 10.1021/acsomega.5c03030. eCollection 2025 Aug 19.
3
Revamping Parkinson's disease therapy using PLGA-based drug delivery systems.

本文引用的文献

1
Brain-targeted glycyrrhizic-acid-loaded surface decorated nanoparticles for treatment of cerebral ischaemia and its toxicity assessment.脑靶向甘草酸载药表面修饰纳米粒治疗脑缺血及其毒性评价。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):475-490. doi: 10.1080/21691401.2018.1561458.
2
Fabrication, Optimization, and Evaluation of Rotigotine-Loaded Chitosan Nanoparticles for Nose-To-Brain Delivery.用于鼻脑递送的罗替戈汀壳聚糖纳米粒的制备、优化及评价
Pharmaceutics. 2019 Jan 10;11(1):26. doi: 10.3390/pharmaceutics11010026.
3
Nose-to-brain delivery of temozolomide-loaded PLGA nanoparticles functionalized with anti-EPHA3 for glioblastoma targeting.
利用基于聚乳酸-羟基乙酸共聚物的药物递送系统改进帕金森病治疗方法。
NPJ Parkinsons Dis. 2025 Aug 20;11(1):248. doi: 10.1038/s41531-025-01081-1.
4
A novel nanocomposite Lf-DA-MSN-PF127 aided the delivery of dopamine for the treatment of Parkinson's disease in a rat model.一种新型纳米复合材料Lf-DA-MSN-PF127有助于在大鼠模型中递送多巴胺以治疗帕金森病。
Nanoscale Adv. 2025 Aug 15. doi: 10.1039/d5na00593k.
5
Role of borneol as enhancer in drug formulation: A review.冰片在药物制剂中作为增溶剂的作用：综述。
Chin Herb Med. 2024 May 17;17(3):473-483. doi: 10.1016/j.chmed.2024.04.003. eCollection 2025 Jul.
6
Nose-to-brain delivery of targeted lipid nanoparticles as two-pronged -amyloid nanoscavenger for Alzheimer's disease therapy.靶向脂质纳米颗粒经鼻至脑递送作为用于阿尔茨海默病治疗的双管齐下的β-淀粉样蛋白纳米清除剂
Acta Pharm Sin B. 2025 Jun;15(6):2884-2899. doi: 10.1016/j.apsb.2025.02.035. Epub 2025 Mar 1.
7
The Nasal-Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases.鼻-脑给药途径：作用机制及其在中枢神经系统疾病中的应用
MedComm (2020). 2025 Jun 6;6(6):e70213. doi: 10.1002/mco2.70213. eCollection 2025 Jun.
8
Recent advances in biomimetic nanodelivery systems for the treatment of depression.用于治疗抑郁症的仿生纳米递送系统的最新进展。
Mater Today Bio. 2025 Apr 17;32:101781. doi: 10.1016/j.mtbio.2025.101781. eCollection 2025 Jun.
9
Transferrin and Borneol-Enhanced Liposomes for Targeted Rapamycin Delivery in TBI.转铁蛋白与冰片增强脂质体用于创伤性脑损伤中雷帕霉素的靶向递送
Int J Nanomedicine. 2025 Apr 11;20:4503-4518. doi: 10.2147/IJN.S489165. eCollection 2025.
10
Trojan Horse Delivery Strategies of Natural Medicine Monomers: Challenges and Limitations in Improving Brain Targeting.天然药物单体的“特洛伊木马”递送策略：改善脑靶向性面临的挑战与局限
Pharmaceutics. 2025 Feb 20;17(3):280. doi: 10.3390/pharmaceutics17030280.
载替莫唑胺的 PLGA 纳米粒经抗 EphA3 修饰后经鼻腔递送至脑内用于脑胶质细胞瘤靶向治疗。
Drug Deliv. 2018 Nov;25(1):1634-1641. doi: 10.1080/10717544.2018.1494226.
4
Improvement of impulse control disorders associated with levodopa-carbidopa intestinal gel treatment in advanced Parkinson's disease.改善晚期帕金森病患者应用左旋多巴-卡比多巴肠凝胶治疗相关的冲动控制障碍。
J Neurol. 2018 Jun;265(6):1279-1287. doi: 10.1007/s00415-018-8803-1. Epub 2018 Mar 20.
5
Striatal changes in Parkinson disease: An investigation of morphology, functional connectivity and their relationship to clinical symptoms.帕金森病纹状体变化：形态、功能连接及其与临床症状关系的研究。
Psychiatry Res Neuroimaging. 2018 May 30;275:5-13. doi: 10.1016/j.pscychresns.2018.03.004. Epub 2018 Mar 7.
6
Delivery of an anti-transthyretin Nanobody to the brain through intranasal administration reveals transthyretin expression and secretion by motor neurons.通过鼻腔内给药将抗转甲状腺素蛋白纳米体递送至大脑，揭示了运动神经元中转甲状腺素蛋白的表达和分泌。
J Neurochem. 2018 Jun;145(5):393-408. doi: 10.1111/jnc.14332. Epub 2018 May 9.
7
Intranasal delivery of Huperzine A to the brain using lactoferrin-conjugated N-trimethylated chitosan surface-modified PLGA nanoparticles for treatment of Alzheimer's disease.使用乳铁蛋白共轭的N-三甲基化壳聚糖表面修饰的聚乳酸-羟基乙酸共聚物纳米颗粒经鼻向脑递送石杉碱甲用于治疗阿尔茨海默病。
Int J Nanomedicine. 2018 Feb 1;13:705-718. doi: 10.2147/IJN.S151474. eCollection 2018.
8
Lactoferrin-modified rotigotine nanoparticles for enhanced nose-to-brain delivery: LESA-MS/MS-based drug biodistribution, pharmacodynamics, and neuroprotective effects.乳铁蛋白修饰的罗替戈汀纳米粒增强经鼻脑递药：基于 LESA-MS/MS 的药物体内分布、药效学和神经保护作用。
Int J Nanomedicine. 2018 Jan 9;13:273-281. doi: 10.2147/IJN.S151475. eCollection 2018.
9
Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer's Disease: Optimization, Biological Efficacy, and Potential Toxicity.鼻内给药的载胡椒碱壳聚糖纳米颗粒用于阿尔茨海默病的脑靶向治疗：优化、生物学疗效及潜在毒性
J Pharm Sci. 2015 Oct;104(10):3544-3556. doi: 10.1002/jps.24557. Epub 2016 Jan 8.
10
Intranasal delivery of quercetin-loaded mucoadhesive nanoemulsion for treatment of cerebral ischaemia.载姜黄素的鼻内给药黏附纳米乳治疗脑缺血。
Artif Cells Nanomed Biotechnol. 2018 Jun;46(4):717-729. doi: 10.1080/21691401.2017.1337024. Epub 2017 Jun 12.