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血管内腹主动脉瘤修复后的长期再干预。

Long-term Reintervention After Endovascular Abdominal Aortic Aneurysm Repair.

机构信息

Section of Vascular Surgery, Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH.

The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine at Dartmouth, Lebanon, NH.

出版信息

Ann Surg. 2021 Jul 1;274(1):179-185. doi: 10.1097/SLA.0000000000003446.

Abstract

OBJECTIVE

To describe the long-term reintervention rate after endovascular abdominal aortic aneurysm repair (EVR), and identify factors predicting reintervention.

SUMMARY OF BACKGROUND DATA

EVR is the most common method of aneurysm repair in America, and reintervention after EVR is common. Clinical factors predicting reintervention have not been described in large datasets with long-term follow-up.

METHODS

We studied patients who underwent EVR using the Vascular Quality Initiative registry linked to Medicare claims. Our primary outcome was reintervention, defined as any procedure related to the EVR after discharge from the index hospitalization. We used classification and regression tree modeling to inform a multivariable Cox-regression model predicting reintervention after EVR.

RESULTS

We studied 12,911 patients treated from 2003 to 2015. Mean age was 75.5 ± 7.3 years, 79.9% were male, and 89.1% of operations were elective. The 3-year reintervention rate was 15%, and the 10-year rate was 33%. Five factors predicted reintervention: operative time ≥3.0 hours, aneurysm diameter ≥6.0 cm, an iliac artery aneurysm ≥2.0 cm, emergency surgery, and a history of prior aortic surgery. Patients with no risk factors had a 3-year reintervention rate of 12%, and 10-year rate of 26% (n = 7310). Patients with multiple risk factors, such as prior aortic surgery and emergent surgery, had a 3-year reintervention rate 72%, (n = 32). Modifiable factors including EVR graft manufacturer or supra-renal fixation were not associated with reintervention (P = 0.76 and 0.79 respectively).

CONCLUSIONS

All patients retain a high likelihood of reintervention after EVR, but clinical factors at the time of repair can predict those at highest risk.

摘要

目的

描述血管内腹主动脉瘤修复(EVR)后的长期再干预率,并确定预测再干预的因素。

摘要背景数据

EVR 是美国最常见的动脉瘤修复方法,EVR 后再干预很常见。在具有长期随访的大型数据集,尚未描述预测再干预的临床因素。

方法

我们使用血管质量倡议登记处与医疗保险索赔相关联,研究了接受 EVR 治疗的患者。我们的主要结果是再干预,定义为从索引住院出院后与 EVR 相关的任何程序。我们使用分类和回归树模型为预测 EVR 后再干预的多变量 Cox 回归模型提供信息。

结果

我们研究了 2003 年至 2015 年期间接受治疗的 12911 名患者。平均年龄为 75.5 ± 7.3 岁,79.9%为男性,89.1%的手术为择期手术。3 年再干预率为 15%,10 年率为 33%。有 5 个因素预测再干预:手术时间≥3.0 小时、动脉瘤直径≥6.0 厘米、髂动脉瘤≥2.0 厘米、急诊手术和主动脉手术史。无危险因素的患者 3 年再干预率为 12%,10 年再干预率为 26%(n = 7310)。有多个危险因素的患者,如主动脉手术史和急诊手术,3 年再干预率为 72%(n = 32)。可改变的因素,包括 EVR 移植物制造商或肾上固定术与再干预无关(P = 0.76 和 0.79)。

结论

所有患者在接受 EVR 后都有很高的再干预可能性,但修复时的临床因素可以预测风险最高的患者。

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