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基于疏水性氧化铁纳米簇的载药诊疗探针用于 MRI 和化疗，多柔比星作为相转移剂。

Vehicle-saving theranostic probes based on hydrophobic iron oxide nanoclusters using doxorubicin as a phase transfer agent for MRI and chemotherapy.

机构信息

Key Laboratory for Green Chemical Process of Ministry of Education, Hubei Key Laboratory for Novel Reactor and Green Chemistry Technology, Hubei Engineering Research Center for Advanced Fine Chemicals, and School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430205, P. R. China.

The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, P. R. China.

出版信息

Chem Commun (Camb). 2019 Aug 7;55(61):9015-9018. doi: 10.1039/c9cc03868j. Epub 2019 Jul 10.

DOI:10.1039/c9cc03868j
PMID:31290867
Abstract

A simple approach for constructing theranostic nanobeads is developed by using doxorubicin as a phase transfer agent to solubilize small iron oxide nanoclusters. The nanobeads can be specifically internalized into cancer cells with the guidance of an external magnetic field, resulting in good MRI and chemotherapy.

摘要

一种简单的构建治疗性纳米珠的方法是利用阿霉素作为相转移剂来溶解小的氧化铁纳米簇。纳米珠可以在外部磁场的引导下特异性地被内吞进入癌细胞，从而实现良好的 MRI 和化疗效果。

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