University Hospital of Fattouma Bourguiba of Monastir, Department of Pharmacology, University of Monastir, Monastir, Tunisia.
University Hospital of Fattouma Bourguiba of Monastir, Department of Dermatology, University of Monastir, Monastir, Tunisia.
Contact Dermatitis. 2019 Nov;81(5):336-340. doi: 10.1111/cod.13351. Epub 2019 Aug 7.
Fixed drug eruption (FDE) represents a drug-related cutaneous reaction. Many drugs been associated with this clinical entity, with continually evolving documentation of implicated agents and clinical presentations. A bullous form can occur although it is rare.
To assess the epidemiological and clinical characteristics of FDE.
We retrospectively analysed all FDE cases who presented to the Clinical Pharmacology Department at the University Hospital, Monastir, Tunisia, for allergy workup.
The mean age of the 41 confirmed FDE cases was 43.8 ± 15.5 years. The time between first lesion onset and FDE diagnosis was less than 1 month for 13 patients (31.7%). Fifteen patients had bullous lesions. The upper limbs were the most common location (65.9% of cases). The patch tests were positive in 27 cases; a provocation test yielded a positive response in the four cases tested. Nonsteroidal anti-inflammatory drugs (NSAIDs) were involved in 51.2%, antibiotics in 24.4%, and other analgesics in 19.5%. The most common offending drug was mefenamic acid in 24.4% of cases. Bullous lesions were significantly associated with paracetamol intake (P = .014; odds ratio 16.7; 95% confidence interval: 1.76-158).
NSAIDs and antibiotics were the most implicated in inducing FDE; paracetamol was associated with bullous lesions.
固定性药疹（FDE）代表一种与药物相关的皮肤反应。许多药物都与这种临床实体有关，其涉及的药物和临床表现不断演变。虽然它很少见，但可能会出现水疱样表现。
评估 FDE 的流行病学和临床特征。
我们回顾性分析了所有在突尼斯莫纳斯提尔大学医院临床药理学系就诊进行过敏检测的 FDE 病例。
41 例确诊 FDE 患者的平均年龄为 43.8 ± 15.5 岁。13 例患者（31.7%）首次发病至 FDE 诊断的时间不到 1 个月。15 例患者有疱性皮损。上肢是最常见的受累部位（65.9%的病例）。27 例患者的斑贴试验阳性；在接受测试的 4 例患者中，激发试验有阳性反应。非甾体抗炎药（NSAIDs）占 51.2%，抗生素占 24.4%，其他镇痛药占 19.5%。最常见的致病药物是 NSAIDs 中的甲芬那酸（24.4%的病例）。疱性皮损与扑热息痛摄入显著相关（P =.014；比值比 16.7；95%置信区间：1.76-158）。
NSAIDs 和抗生素是诱导 FDE 最常见的药物；扑热息痛与疱性皮损相关。
