Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science , Soochow University , Suzhou 215123 , China.
Department of Anesthesiology and Critical Care Medicine, Zhongshan Hospital , Fudan University , Shanghai 200438 , China.
Biomacromolecules. 2019 Aug 12;20(8):3161-3170. doi: 10.1021/acs.biomac.9b00741. Epub 2019 Jul 25.
Fluorescent imidazolium-type poly(ionic liquid)s (PIL)s were synthesized by anion exchange of bromide (Br) in poly(3-butyl-1-vinylimidazolium bromide) (PIL-Br) with a fluorescent anion, namely, 3-(4-(1,2,2-triphenylvinyl)phenoxy)propane-1-sulfonate (TPESO). Such an anion exchange provided antibacterial PILs with aggregation-induced emission (AIE) properties that simultaneously kill and image bacteria. These fluorescence and antibacterial properties could be regulated by controlling the Br/TPESO ratio. The fluorescence intensity increases as this ratio increases, while the antibacterial property exhibits an opposite trend. Moreover, the AIE-type PILs are useful for fluorescently imaging dead bacteria (macroscopically and microscopically) and could effectively inhibit biofilm growth. This study provided a convenient method to obtain fluorescent PILs with adjustable antibacterial and imaging properties.
荧光咪唑型聚（离子液体）（PIL）是通过溴化物（Br）在聚（3-丁基-1-乙烯基咪唑溴化物）（PIL-Br）中的阴离子交换反应与荧光阴离子，即 3-（4-（1,2,2-三苯基乙烯基）苯氧基）丙烷-1-磺酸盐（TPESO）制得。这种阴离子交换反应提供了具有聚集诱导发光（AIE）性质的抗菌 PIL，可同时杀死和成像细菌。这些荧光和抗菌性能可以通过控制 Br/TPESO 比来调节。随着 Br/TPESO 比的增加，荧光强度增加，而抗菌性能则呈现相反的趋势。此外，AIE 型 PIL 可用于荧光成像死菌（宏观和微观），并能有效抑制生物膜的生长。本研究提供了一种简便的方法来获得具有可调抗菌和成像性能的荧光 PIL。
