Liu Xiaokun, Zhang Zhiying, Tomczak Nikodem, Yang Cong, Li Chengjun, Liu Rongrong, Yan Bing
Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University Guangzhou 510006 China
Southern Marine Science and Engineering Guangdong Laboratory Zhuhai 519000 China.
Nanoscale Adv. 2023 Feb 20;5(6):1631-1635. doi: 10.1039/d2na00951j. eCollection 2023 Mar 14.
Bacterial infections have posed significant threats to public health due to the emergence of antibiotic resistance. In this work, a novel antibacterial composite nanomaterial based on spiky mesoporous silica spheres loaded with poly(ionic liquid)s and aggregation-induced emission luminogens (AIEgens) was designed for efficient multidrug-resistant (MDR) bacteria treatment and imaging. The nanocomposite exhibited excellent and long-term antibacterial activity towards both Gram-negative and Gram-positive bacteria. Meanwhile, fluorescent AIEgens facilitate real-time bacterial imaging. Our study provides a multifunctional platform and a promising alternative to antibiotics for combating pathogenic MDR bacteria.
由于抗生素耐药性的出现，细菌感染对公共卫生构成了重大威胁。在这项工作中，设计了一种基于负载聚（离子液体）和聚集诱导发光剂（AIEgens）的尖刺介孔二氧化硅球的新型抗菌复合纳米材料，用于高效治疗多重耐药（MDR）细菌并进行成像。该纳米复合材料对革兰氏阴性菌和革兰氏阳性菌均表现出优异且持久的抗菌活性。同时，荧光AIEgens有助于实时细菌成像。我们的研究为对抗致病性MDR细菌提供了一个多功能平台和一种有前景的抗生素替代品。
