Brailowsky S, Kunimoto M, Menini C, Silva-Barrat C, Riche D, Naquet R
Laboratoire de Physiologie Nerveuse, C.N.R.S., Gif-sur-Yvette, France.
Brain Res. 1988 Feb 23;442(1):175-9. doi: 10.1016/0006-8993(88)91448-5.
A novel model of focal, cortical epilepsy is described. Chronic (6 h to 14 days), localized application of gamma-aminobutyric acid (GABA) into the somatomotor cortex of rats induces, upon withdrawal, the appearance of epileptogenic activity with maximal electrographic expression circumscribed to the infused site. This GABA-withdrawal syndrome (tested for a 100 micrograms/microliter/h dose) lasted from 24 to 168 h (mean values). A significant correlation was found between infusion time and duration of the excitability rebound, with the longer duration corresponding to the shorter infusion time. A distant lesion effect was observed in the thalamic area of cortical projection. The potential use of this neurotransmitter-induced phenomenon in the study of brain plasticity in general, and of epilepsy in particular, is discussed.
本文描述了一种新型局灶性皮质癫痫模型。将γ-氨基丁酸（GABA）长期（6小时至14天）局部应用于大鼠躯体运动皮层，撤药后会诱发癫痫源性活动，其最大电图表现局限于注入部位。这种GABA撤药综合征（以100微克/微升/小时的剂量进行测试）持续24至168小时（平均值）。发现输注时间与兴奋性反弹持续时间之间存在显著相关性，持续时间越长对应输注时间越短。在皮质投射的丘脑区域观察到远距离损伤效应。本文还讨论了这种神经递质诱导现象在一般脑可塑性研究，特别是癫痫研究中的潜在用途。
